ATRX Polyclonal Antibody

货号：PA5-21348

规格：100 µL

价格：5935

产品类型：标签抗体

品牌：Thermo Fisher

抗原：Recombinant fragment corresponding to a region wit

物种：人/小鼠/大鼠

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	一抗	同型对照：
浓度：	0.66mg/mL	用法：	1:100-1:1000（ICC）；1:100-1:1000(IF);1:100-1:1000(IHC(P)）;1:100-1:500(IP);1:500-1:3000(WB)

产品详细信息Recommended positive controls: 293T, A431, HeLa, HepG2, NIH3T3, PC-12, Rat-2.Predicted reactivity: Mouse (97%), Chimpanzee (100%).Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.靶标信息ATRX encodes a protein that contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

数据：

ATRX Antibody (PA5-21348) in ICCImmunocytochemistry-Immunofluorescence analysis of ATRX was performed in HeLa cells fixed in 4% paraformaldehyde at RT for 15 min. Green: ATRX Polyclonal Antibody (Product # PA5-21348) diluted at 1:1500. Red: phalloidin, a cytoskeleton marker. ATRX Antibody (PA5-21348) in IHC (P)Immunohistochemistry (Paraffin) analysis of ATRX was performed in paraffin-embedded human breast carcinoma tissue using ATRX Polyclonal Antibody (Product # PA5-21348) at a dilution of 1:2000. ATRX Antibody (PA5-21348)Antibody specificity was demonstrated by shRNA mediated knockdown of the target protein. 293T were transfected with ATRX shRNA and decrease in signal intensity was observed in western blot application using ATRX antibody (Product # PA5-21348).Knockdown validation info.

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