CBX4 Polyclonal Antibody

货号：PA5-109482

规格：100 µL

价格：4711

产品类型：标签抗体

品牌：Thermo Fisher

抗原：Recombinant fusion protein containing a sequence c

物种：人/小鼠

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	一抗	同型对照：
浓度：	1.07 mg/mL	用法：	1:50-1:200（IHC(P)）；1:50-1:200（IP）；1:500-1:2000(WB）

产品详细信息Sequence of this protein is as follows: AVGLNLSHVRKRCLSETHGEREPCKKRLTARSISTPTCLGGSPAAERPADLPPAAALPQPEVILLDSDLDEPIDLRCVKTRSEAGEPPSSLQVKPETPASAAVAVAAAAAPTTTAEKPPAEAQDEPAESLSEFKPFFGNIIITDVTANCLTVTFKEYVTV靶标信息Polycomb group (PcG) proteins are chromatin-associated proteins which are important for embryonic and adult stem cell self-renewal and maintenance. At least two distinct human PcG complexes have been identified. Polycomb repressive complex I (PRC1) contains CBX4/Pc2, HPH1 and RING domain-containing proteins (RING1, RING2 and BMI1). CBX4 (Chromobox protein homolog 4 or PC2), which functions as a transcriptional suppressor, is a candidate of KyoT2-binding proteins. It is a E3 SUMO-protein ligase which facilitates SUMO1 conjugation. Depletion of CBX4 results in decreased cellular resistance to ionizing radiation. CBX4 is directly involved in the cellular response to DNA damage.

数据：

CBX4 Antibody (PA5-109482) in IHC (P)Immunohistochemistry analysis of CBX4 in paraffin-embedded human lung cancer tissue. Samples were incubated in polyclonal CBX4 antibody (Product # PA5-109482) using a dilution of 1:100. CBX4 Antibody (PA5-109482) in WBWestern blot analysis of CBX4 in HepG2, mouse liver. Samples were incubated in polyclonal CBX4 antibody (Product # PA5-109482) using a dilution of 1:1000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10000.

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