JARID1C Polyclonal Antibody

货号：PA5-83807

规格：100 µL

价格：6049

产品类型：标签抗体

品牌：Thermo Fisher

抗原：Recombinant protein corresponding to Human KDM5C

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	一抗	同型对照：
浓度：	0.2 mg/mL	用法：	0.25-2 µg/mL（ICC）；0.25-2 µg/mL(IF)

产品详细信息Immunogen sequence: LGLMAKDKTL RKKDKEGPEC PPTVVVKEEL GGDVKVESTS PKTFLESKEE LSHSPEPCTK MTMRLRRNHS NAQFIESYVC RMCSRG靶标信息Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.; Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.

数据：

JARID1C Antibody (PA5-83807) in IFImmunofluorescent analysis of JARID1C in HEK 293 cells using a JARID1C polyclonal antibody (Product # PA5-83807). The analysis shows localization to nucleoplasm and cytosol.

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技术参数

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