Mouse EGFR/ErbB1 ELISA Kit ELISA试剂盒,Mouse EGFR/ErbB1 ELISA Kit/小鼠EGFR / ErbB1 ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Mouse EGFR/ErbB1 ELISA Kit ELISA试剂盒,Mouse EGFR/ErbB1 ELISA Kit/小鼠EGFR / ErbB1 ELISA试剂盒

2024-10-24

Mouse EGFR/ErbB1 ELISA Kit/小鼠EGFR / ErbB1 ELISA试剂盒

货号：EM23RB,EM23RBX5,EM23RBX10

规格：96 Tests,5X96 Tests,10X96 tests

价格：6641,29884,57271

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：小鼠

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	0.2 ng/mL
检测范围	0.2-50 ng/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	<12%
批内变异系数（CV）	<10%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	5 x 96 Tests
组份	- 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	EGFR
Protein aliases	avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, Epidermal growth factor receptor, waved 2
物种（Tested）	小鼠
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	9030024J15Rik, AI552599, Egfr, Erbb, Errb1, Errp, wa-2, wa2, Wa5
Gene ID	(Mouse) 13649
Gene symbol	Egfr
UniProt ID	(Mouse) Q01279

Mouse EGFR/ErbB1 quantitates mouse EGFR/ErbB1 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant mouse EGFR/ErbB1.小鼠EGFR / ErbB1定量分析血清，血浆，上清液中的小鼠EGFR / ErbB1。该检测试剂盒将专门识别天然和重组小鼠EGFR / ErbB1。Target information 靶标信息EGFR (Epidermal growth factor receptor, HER1, ErbB1) is encoded by the EGFR gene located on chromosome 7 in humans. EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. Phosphorylation of EGFR at certain residues is also mediated by Src-non-receptor kinase. EGFR activation signals multiple downstream signaling cascades such as the Ras - ERK, PI3-K - Akt, Jak - STAT and PKC pathways that help in growth and proliferation of cells. Phosphorylation of EGFR at Y1086 specifically allows binding of the adaptor protein GRB2, leading to activation of the MAPK pathway. Upon receptor activation and signaling, EGFR is endocytosed and targeted for degradation or recycling. Mutations in the EGFR gene are associated with lung cancer and multiple alternatively spliced transcript variants encode different protein isoforms of EGFR have been found. Increased production or activation of EGFR has been associated with poor prognosis in a variety of tumors. Moreover, EGFR overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.EGFR（表皮生长因子受体，HER1，ErbB1）由位于人第7号染色体上的EGFR基因编码。 EGFR属于HER / ERbB蛋白质家族，包括其他三个受体酪氨酸激酶ERbB2，ERbB3，ERbB4。 EGFR是跨膜受体，其相关配体（例如EGF（表皮生长因子）和TGFα（转化生长因子α））与细胞外域的结合会导致EGFR二聚化，随后胞质域中酪氨酸残基的自磷酸化。 Src-非受体激酶还介导某些残基上EGFR的磷酸化。 EGFR激活向多个下游信号传导级联发出信号，例如Ras-ERK，PI3-K-Akt，Jak-STAT和PKC途径，有助于细胞的生长和增殖。 EGFR在Y1086处的磷酸化可特异性结合衔接子蛋白GRB2，从而激活MAPK途径。在受体激活和信号传导后，EGFR被内吞并靶向降解或再循环。 EGFR基因的突变与肺癌有关，并且发现了多个交替剪接的转录变体编码EGFR的不同蛋白亚型。 EGFR的产生或激活增加与多种肿瘤的不良预后有关。此外，在头颈部，脑，膀胱，胃，乳腺，肺，子宫内膜，子宫颈，外阴，卵巢，食道，胃和鳞状细胞癌中观察到EGFR过表达。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

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Mouse EGFR/ErbB1 ELISA Kit ELISA试剂盒,Mouse EGFR/ErbB1 ELISA Kit/小鼠EGFR / ErbB1 ELISA试剂盒

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