Mouse Endostatin ELISA Kit ELISA试剂盒,Mouse Endostatin ELISA Kit/小鼠内皮抑素ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Mouse Endostatin ELISA Kit ELISA试剂盒,Mouse Endostatin ELISA Kit/小鼠内皮抑素ELISA试剂盒

2024-10-24

Mouse Endostatin ELISA Kit/小鼠内皮抑素ELISA试剂盒

货号：EM25RB,EM25RBX5,EM25RBX10

规格：96 Tests,5X96 Tests,10X96 tests

价格：6641,29884,57271

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：小鼠

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	2.5 ng/mL
检测范围	2.458-600 ng/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	<12%
批内变异系数（CV）	<10%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	5 x 96 Tests
组份	- 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	Endostatin
Protein aliases	Collagen alpha-1(XVIII) chain, Endostatin, NC1, Non-collagenous domain 1, procollagen, type XVIII, alpha 1
物种（Tested）	小鼠
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	Col18a1
Gene ID	(Mouse) 12822
Gene symbol	Col18a1
UniProt ID	(Mouse) Q61437

Mouse Endostatin quantitates mouse Endostatin in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant mouse Endostatin.小鼠内皮抑素定量测定血清，血浆，上清液中的小鼠内皮抑素。该检测试剂盒将专门识别天然和重组小鼠内皮抑素。Target information 靶标信息Endostatin is able to avoke non-uniform response for proliferation, cell mount and migration of entothelial cells, which different endostatin binding characteristic, leads to the assumption that endostatin effect is strongly dependent from endothelial cell type. Furthermore endostatin inhibits angiogenesis and tumor growth in vivo by inducing apoptosis in endothelial cells. The local delivery of endostatin seems to specifically affect tumor-associated microvessels by reduction of the vessel density, diameter and functionality. Tumor cell migration and invasion was greatly reduced in the endostatin treated animals. Endostatin is non-toxic and does not induce aquired drug resistance and has therefor become a potent new therapy strategy in solid neoplasias. This therapy appears to have a high potential not only for the treatment of gliomas, the most common brain tumors, but also in other tumors. The ability of endostatin to inhibit neoangiogenesis is mediated, at least in part, by Zn^+2 binding and elastase processing. Widespread endostatin expression was found in elactic fibers in vessel walls and in some other basement membrane zones. Endostatin is released by neurons to accumulate in amyloid plaques in Alzheimer's disease.内皮抑素能够引起内皮细胞增殖，细胞贴壁和迁移的非均匀反应，这与内皮抑素的不同结合特征导致内皮抑素的作用强烈依赖于内皮细胞类型的假设。此外，内皮抑素通过在内皮细胞中诱导凋亡来抑制体内的血管生成和肿瘤生长。内皮抑素的局部递送似乎通过降低血管密度，直径和功能来特异性地影响与肿瘤相关的微血管。在内皮抑素治疗的动物中，肿瘤细胞的迁移和侵袭大大减少。内皮抑素是无毒的，不会诱导获得性耐药，因此已成为实体瘤形成中一种有效的新治疗策略。这种疗法似乎不仅具有治疗神经胶质瘤（最常见的脑部肿瘤）的潜力，而且在其他肿瘤中也具有很高的潜力。内皮抑素抑制新血管生成的能力至少部分地通过Zn 2+结合和弹性蛋白酶加工介导。在血管壁和其他一些基底膜区域的纤维中发现内皮抑素的表达广泛。神经元释放内皮抑素，从而在阿尔茨海默氏病中积聚在淀粉样斑块中。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

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Mouse Endostatin ELISA Kit ELISA试剂盒,Mouse Endostatin ELISA Kit/小鼠内皮抑素ELISA试剂盒

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