Mouse Fas L ELISA Kit ELISA试剂盒,Mouse Fas L ELISA Kit/小鼠Fas L ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Mouse Fas L ELISA Kit ELISA试剂盒,Mouse Fas L ELISA Kit/小鼠Fas L ELISA试剂盒

2024-10-24

Mouse Fas L ELISA Kit/小鼠Fas L ELISA试剂盒

货号：EM29RB,EM29RBX5,EM29RBX10

规格：96 Tests,5X96 Tests,10X96 tests

价格：6641,29884,57271

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：小鼠

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	8 pg/mL
检测范围	8-2,000 pg/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	<12%
批内变异系数（CV）	<10%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	5 x 96 Tests
组份	- 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	Fas Ligand (CD178)
Protein aliases	ADAM10-processed FasL form, APL, CD178, CD95 ligand, CD95-L, Fas antigen ligand, Fas ligand, FasL ICD, FasL intracellular domain, generalized lymphoproliferative disease, Receptor-binding FasL ectodomain, sFasL, Soluble Fas ligand, SPA, SPPL2A-processed FasL form, Tumor necrosis factor ligand superfamily member 6, membrane form, soluble form
物种（Tested）	小鼠
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	APT1LG1, CD178, CD95-L, CD95L, Fas-L, Fasl, Faslg, gld, Tnfsf6
Gene ID	(Mouse) 14103
Gene symbol	Fasl
UniProt ID	(Mouse) P41047

Mouse Fas L quantitates mouse Fas L in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant mouse Fas L.小鼠Fas L定量分析血清，血浆，上清液中的小鼠FasL。该检测试剂盒将只识别天然和重组小鼠FasL。Target information 靶标信息CD178 (Fas ligand, FasL) is a type-II-membrane protein, whose N-terminus is in the cytoplasm and its C-terminal region extends into the extracellular space. Its receptor, FasR, is a cell-surface-type-I-membrane protein and a member of the tumor necrosis factor (TNF) and nerve growth factor (NGF) receptor family. As a member of the TNF-cytokine family CD178 induces apoptosis when interacting with FasR. CD178 may exist as either membrane bound (45 kD) or soluble forms (26 kD). The soluble protein can be released from cells upon cleavage by metalloproteinases. Binding of CD178 to Fas leads to oligomerization of the receptor and triggers apoptotic cell death through the interaction of other proteins. CD178 is predominantly expressed in activated T-lymphocytes and natural killer (NK) cells also it is expressed in the tissues of immune-privilege sites such as testis and eye. CD178 expression is also reported in various tissues as thymus, liver, ovary, lung, heart and kidney. It is assumed that induction of apoptosis through CD178 is predominantly involved in anti-viral immune responses. CD178 is a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis. Various cells express FAS, where CD178 is expressed predominantly on activated T cells. FAS and CD178 are involved in the down-regulation of immune reactions as well as T cell-mediated cytotoxicity. CD178 concentration has also been shown to be associated with atherosclerosis and inflammatory disease, in patients with hypertension. The Fas/ CD178 system has been shown to play a role in a number of human diseases, for example AIDS, hepatitis or cancer.CD178（Fas配体，FasL）是一种II型膜蛋白，其N端位于细胞质中，其C端区域延伸到细胞外空间。它的受体FasR是一种细胞表面I型膜蛋白，是肿瘤坏死因子（TNF）和神经生长因子（NGF）受体家族的成员。作为TNF细胞因子家族的成员，CD178与FasR相互作用时可诱导细胞凋亡。 CD178可以膜结合（45 kD）或可溶形式（26 kD）形式存在。可溶性蛋白可在被金属蛋白酶切割后从细胞中释放出来。 CD178与Fas的结合导致受体的寡聚，并通过其他蛋白质的相互作用触发凋亡性细胞死亡。 CD178主要在活化的T淋巴细胞和自然杀伤（NK）细胞中表达，还可以在免疫特权部位的组织（例如睾丸和眼睛）中表达。在胸腺，肝脏，卵巢，肺，心脏和肾脏的各种组织中也有CD178表达的报道。假定通过CD178诱导细胞凋亡主要与抗病毒免疫反应有关。 CD178是属于肿瘤坏死因子家族的细胞表面分子，与其受体Fas结合，从而诱导细胞凋亡。各种细胞表达FAS，其中CD178主要在活化的T细胞上表达。 FAS和CD178参与免疫反应的下调以及T细胞介导的细胞毒性。在高血压患者中，CD178的浓度也被证明与动脉粥样硬化和炎性疾病有关。 Fas / CD178系统已显示出在许多人类疾病（例如艾滋病，肝炎或癌症）中的作用。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

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Mouse Fas L ELISA Kit ELISA试剂盒,Mouse Fas L ELISA Kit/小鼠Fas L ELISA试剂盒

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