Thermo KIR2D Monoclonal Antibody (NKVFS1),KIR2D Monoclonal Antibody (NKVFS1)

2024-10-24

KIR2D Monoclonal Antibody (NKVFS1)

货号:MA1-82651

规格:100μg

价格:5462

产品类型:流式抗体

品牌:Thermo Fisher

物种:人

宿主:小鼠

抗体亚型:IgG1, kappa

克隆号: NKVFS1

荧光染料:Alexa Fluor 488

抗体类型 单抗同型对照:IgG
浓度:1 mg/mL用法:Assay Dependent (ELISA);1:50-1:100(Flow);Assay Dependent (IP);Assay Dependent (WB)
产品详细信息Clone NKVFS1 recognizes the long and short forms CD158a and CD158b (KIR2DL, KIR2DS1 and KIR2DS2 respectively) and also p50.3 (KIR2DS4). This clone is reported to have functional activity, activating NK cell cytotoxicity via KIR2DS and inhibiting via KIR2DL forms.For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.靶标信息Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several ""framework"" genes are found in all haplotypes. The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
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