HLA-DR Monoclonal Antibody (LN3), eFluor 450 Thermo 48-9956-42 HLA-DR Monoclonal Antibody (LN3), eFluor 450-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

HLA-DR Monoclonal Antibody (LN3), eFluor 450 Thermo 48-9956-42 HLA-DR Monoclonal Antibody (LN3), eFluor 450

2024-10-28

HLA-DR Monoclonal Antibody (LN3), eFluor 450

货号：48-9956-42

规格：100 Tests

市场价格：2844

产品类型：流式抗体

品牌：Thermo Fisher

物种：人

宿主：小鼠

抗体亚型：IgG2b, kappa

荧光染料：Alexa Fluor 488

抗体类型	一抗	同型对照：	Mouse IgG2b kappa Isotype Control (eBMG2b), eFluor 450
浓度：	5 µL/Test	用法：	5 μL (0.125 μg)/test (Flow)
产品详细信息Description: The LN3 mAb reacts with the human major histocompatibility complex (MHC) class II, HLA-DR. HLA-DR is expressed on the surface of human antigen presenting cells (APC) including B cells, monocytes, macrophages, DCs, and activated T cells. HLA-DR is a heterodimeric transmembrane protein composed of alpha and beta subunits and plays an important role in the presentation of peptides to CD4^+ T lymphocytes.Applications Reported: This LN3 antibody has been reported for use in flowcytometric analysis.Applications Tested: This LN3 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.125 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.eFluor® 450 is an alternative to Pacific Blue®. eFluor® 450 emits at 445 nm and is excited with the Violet laser (405 nm). Please make sure that your instrument is capable of detecting this fluorochome.Excitation: 405 nm; Emission: 445 nm; Laser: Violet Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. Within the DR molecule the beta chaincontains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response.
数据
HLA-DR Antibody (48-9956-42) in FlowStaining of normal human peripheral blood cells with Mouse IgG2b K Isotype Control eFluor® 450 (Product # 48-4732-82) (blue histogram) or Anti-Human HLA-DR eFluor® 450 (purple histogram). Cells in the lymphocyte (left) or monocyte (right) gate were used for analysis.
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参考文献：
1.Frontiers in molecular neuroscienceIncreased White Matter Inflammation in Aging- and Alzheimer's Disease Brain."Published figure using HLA-DR monoclonal antibody (Product # 48-9956-42) in Immunohistochemistry"2.mAbsImproved in vitro and in vivo activity against CD303-expressing targets of the chimeric 122A2 antibody selected for specific glycosylation pattern."48-9956 was used in Flow cytometry/Cell sorting to indicate that ch122A2 mAb could represent a promising cytotoxic mAb candidate for pathologies requiring a decrease in type I IFNs or pDCs."3.Cell reportsLarge-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and Heterogeneity."Published figure using HLA-DR monoclonal antibody (Product # 48-9956-42) in Flow Cytometry"4.Stem cell research & therapyComprehensive characterization of chorionic villi-derived mesenchymal stromal cells from human placenta."48-9956 was used in Western Blotting to study how besides SOX2 expression, no other pluripotency features were observed in early and late passages of CV-MSC."5.OncotargetHDAC inhibition potentiates immunotherapy in triple negative breast cancer."Published figure using HLA-DR monoclonal antibody (Product # 48-9956-42) in Flow Cytometry"

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HLA-DR Monoclonal Antibody (LN3), eFluor 450 Thermo 48-9956-42 HLA-DR Monoclonal Antibody (LN3), eFluor 450

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