HLA-DR Monoclonal Antibody (LN3), PE Thermo 12-9956-41 HLA-DR Monoclonal Antibody (LN3), PE-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

HLA-DR Monoclonal Antibody (LN3), PE Thermo 12-9956-41 HLA-DR Monoclonal Antibody (LN3), PE

2024-10-28

HLA-DR Monoclonal Antibody (LN3), PE

货号：12-9956-41,12-9956-42

规格：25 Tests,100 Tests

市场价格：1029,2303

产品类型：流式抗体

品牌：Thermo Fisher

物种：人

宿主：小鼠

抗体亚型：IgG2b, kappa

荧光染料：PE

抗体类型	一抗	同型对照：	Mouse IgG2b kappa Isotype Control (eBMG2b), PE
浓度：	5 µL/Test	用法：	5 μL (0.07 μg)/test (Flow)
产品详细信息Description: The LN3 mAb reacts with the human major histocompatibility complex (MHC) class II, HLA-DR. HLA-DR is expressed on the surface of human antigen presenting cells (APC) including B cells, monocytes, macrophages, DCs, and activated T cells. HLA-DR is a heterodimeric transmembrane protein composed of alpha and beta subunits and plays an important role in the presentation of peptides to CD4^+ T lymphocytes.Applications Reported: The LN3 antibody has been reported for use in flowcytometric analysis.Applications Tested: The LN3 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.007 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. Within the DR molecule the beta chaincontains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response.
数据
HLA-DR Antibody (12-9956-41) in FlowStaining of normal human peripheral blood cells with Mouse IgG2b K Isotype Control PE (Product # 12-4732-81) (blue histogram) or Anti-Human HLA-DR PE (purple histogram). Cells in the lymphocyte (left) or monocyte (right) gate were used for analysis.
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参考文献：
1.Journal of immunology (Baltimore, Md. : 1950)Dendritic cells derived from hemozoin-loaded monocytes display a partial maturation phenotype that promotes HIV-1 trans-infection of CD4+ T cells and virus replication."12-9956 was used in Flow cytometry/Cell sorting to investigate the effect of malarial pigment hemozoin on HIV-1 transmission, showing that hemozoid-loaded monocytes promote HIV-1 trans-infection and replication."2.Journal of immunology (Baltimore, Md. : 1950)Down-regulation of MHC class II expression through inhibition of CIITA transcription by lytic transactivator Zta during Epstein-Barr virus reactivation."12-9956 was used in Flow cytometry/Cell sorting to indicate that Zta may act as an inhibitor of the MHC class II pathway, suppressing CIITA transcription."3.The Journal of experimental medicineCX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22."12-9956 was used in Flow cytometry/Cell sorting to study the role of CX3CR1+ mononuclear phagocytes in the development of colitis and disease progression following Citrobacter rodentium infection."4.OncotargetSurrogate in vitro activation of innate immunity synergizes with interleukin-7 to unleash rapid antigen-driven outgrowth of CD4+ and CD8+ human peripheral blood T-cells naturally recognizing MUC1, HER2/neu and other tumor-associated antigens.5.cientific reportsAllostimulatory capacity of conditionally immortalized proximal tubule cell lines for bioartificial kidney application."12-9956 was used in Flow cytometry/Cell sorting to assess the immunosafety of conditionally immortalized proximal tubule cell lines for use in bioartificial kidneys, specifically by investigating their allogeneic efects."

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HLA-DR Monoclonal Antibody (LN3), PE Thermo 12-9956-41 HLA-DR Monoclonal Antibody (LN3), PE

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