CD23 Monoclonal Antibody (B3B4), eFluor 450, eBioscience
货号:48-0232-80,48-0232-82
规格:25 μg,100 μg
市场价格:1038,2630
产品类型:流式抗体
品牌:eBioscience
抗原:CD23
物种:小鼠
宿主:大鼠
抗体亚型:IgG2a, kappa
克隆号:B3B4
荧光染料:Alexa Fluor 488
类型: | 流式抗体 | 同型对照: | Rat IgG2a kappa Isotype Control (eBR2a), eFluor 450, eBioscience |
浓度: | 0.2 mg/mL | 用法: | 0.5 μg/test(Flow) |
产品详细信息Description:
The B3B4 monoclonal antibody reacts with mouse CD23, a 45 kDa type II transmembrane glycoprotein. CD23 is expressed on resting conventional B cells, and its expression is modulated upon B-cell activation. B-1 cell lineage (CD5+ B cells) does not express CD23. Soluble forms of the antigen have been reported to be biologically active. CD23 is a low affinity receptor for IgE and is thought to play a role in the regulation of IgE response and B-cell activation. CD21 is thought to bind to CD23.Applications Reported: This B3B4 antibody has been reported for use in flow cytometric analysis.Applications Tested: This B3B4 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.eFluor® 450 is an alternative to Pacific Blue®. eFluor® 450 emits at 445 nm and is excited with the Violet laser (405 nm). Please make sure that your instrument is capable of detecting this fluorochome.Excitation: 405 nm; Emission: 445 nm; Laser: Violet Laser.Filtration: 0.2 µm post-manufacturing filtered.
靶标信息
CD23 is a 45 kDa glycoprotein which is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. The CD23 molecule is identical to the low affinity IgE receptor found on B cells. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic lymphocyctic leukaemia and some cases of centroblastic/centrocytic lymphoma. CD23 is present on a subpopulation of freshly isolated peripheral blood andtonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. Functionally, CD23 is involved in B cell growth and differentiation, and IgE production. Further, CD23 has a soluble form that is a potent mitogenic factor. Diseases associated with CD23 dysfunction include chronic conjunctivitis and chronic lymphocytic leukemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
数据 |
CD40 Antibody (62-0401-82) in FlowStaining of BALB/c splenocytes with Anti-Mouse CD19 FITC (Product # 11-0193) and 0.25 µg of Rat IgG2a K Isotype Control Super Bright 436 (Product # 62-4321) (left) or 0.25 µg of Anti-Mouse CD40 Super Bright 436 (Product # 62-0401) (right). Total viable cells were used for analysis. |
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参考文献: |
1.PloS oneThe nucleosome (histone-DNA complex) is the TLR9-specific immunostimulatory component of Plasmodium falciparum that activates DCs."15-0862 was used in Flow cytometry/Cell sorting to provide a significant insight into the activation of DCs by malaria parasites."2.Experimental and therapeutic medicineLung dendritic cells undergo maturation and polarization towards a T helper type 2-stimulating phenotype in a mouse model of asthma: Role of nerve growth factor."Published figure using CD86 (B7-2) monoclonal antibody (Product # 15-0862-82) in Flow Cytometry"3.Nature communicationsInjectable cryogel-based whole-cell cancer vaccines."Published figure using CD86 (B7-2) monoclonal antibody (Product # 15-0862-82) in Flow Cytometry" |
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