Rabbit anti Human p27/kip1 antibody BIO-RAD VPA00721 Rabbit anti Human p27/kip1 antibody-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Rabbit anti Human p27/kip1 antibody BIO-RAD VPA00721 Rabbit anti Human p27/kip1 antibody

2024-10-28

Rabbit anti Human p27/kip1 antibody

货号：VPA00721

规格：100μl

市场价格：4097

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：p27/kip1

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：Purified

产品介绍
Rabbit anti Human p27/kip1 antibodyrecognizes the cyclin-dependent kinase inhibitor 1, also known as CDK-interacting protein 1, KIP1, BWS, P27KIP1 or wild-type p53-activated fragment 1.The CDKN1A gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of CDKN1A is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for CDKN1A (provided by RefSeq, Nov 2010).Rabbit anti Human p27/kip1 antibody detects a band of 27 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
Preparation	Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution	TRIS buffered glycine.
Preservative Stabilisers	0.01% Thiomersal<50% Glycerol
Immunogen	Recombinant protein encompassing part of the center region of human p27/kip1
Acknowledgements	PrecisionAb is a trademark of Bio-Rad Laboratories.
Regulatory	For research purposes only
Guarantee	12 months from date of despatch.
存储条件
Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
应用
Application Name	Verified	Min Dilution	Max Dilution
Western Blotting	√	1/1000
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.Flow CytometryUse 10ul of the suggested working dilution to label 106cells or 100ul human whole blood.
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技术参数

产品应用 wb

产品类型多克隆抗体

推荐用于 wb

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Rabbit anti Human p27/kip1 antibody BIO-RAD VPA00721 Rabbit anti Human p27/kip1 antibody

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