Mouse anti Human CD49d monoclonal antibody, clone 44H6 BIO-RAD MCA923F Mouse anti Human CD49d monoclonal antibody, clone 44-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Mouse anti Human CD49d monoclonal antibody, clone 44H6 BIO-RAD MCA923F Mouse anti Human CD49d monoclonal antibody, clone 44

2024-10-29

Mouse anti Human CD49d monoclonal antibody, clone 44H6

货号：MCA923F

规格：0.1 mg

市场价格：2831

产品类型：流式抗体

品牌：Bio-Rad

抗原：CD49d

物种：人

宿主：小鼠

抗体亚型：IgG1

克隆号：44H6

荧光染料：FITC

产品介绍
Mouse anti Human CD49d monoclonal antibody, clone 44H6recognizes human CD49d also known as integrin alpha-4 or VLA-4 subunit alpha. CD49d is a ~150kDa single pass type 1 transmembrane glycoprotein with sevenFG-GAPrepeats, characteristic of alpha integrins, in its extracellular domain. CD49d can be proteolytically cleaved to yield fragments of 80 and 70 kDa (Hemleret al.1987). CD49d associates with eitherCD29to form VLA-4 or with Integrin beta-7 to form The Peyer's patches-specific homing receptor LPAM-1, involved in the lymphocyte migration and homing to gut-associated lymphoid tissue (Sackstein 2006) through its interaction with MadCam-1, preferentially expressed on Peyer's patch high endothelial venules and postcapillary venules in lamina propria (Briskinet al.1997)Mouse anti human CD49d, clone 44H6 is reported to induce homotypic aggregation of pre-B cell lines includingHOONandNALM-6(Letarteet al.1993).Mouse anti Human CD106 antibody, clone 1.G11B1recognizes human VCAM-1, a ~110 kDa molecule whose ligand is VLA4. The antigen is expressed on activated endothelial cells and on some tissue macrophages, bone marrow fibroblasts and myoblasts.Mouse anti Human CD106 antibody, clone 1.G11B1 inhibits cellular adhesion mediated by VCAM-1 (Patel 1998).
产品详情
Target Species	Human
Product Form	Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid
Preparation	Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Immunogen	HOON pre-B leukaemia cell line.
Buffer Solution	Phosphate buffered saline
Fusion Partners	Spleen cells from immunised BALB/c mice were fused with cells of the SP2.0-Ag14 mouse myeloma cell line.
Preservative Stabilisers	0.09% Sodium Azide (NaN3)1% Bovine Serum Albumin
Approx. Protein Concentrations	IgG concentration 0.1 mg/ml
Max Ex/Em	Fluorophore	Excitation Max (nm)	Emission Max (nm)
FITC	490	525
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
Flow Cytometry	√	Neat
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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文献
1.Quackenbush, E.J. & Letarte, M. (1985) Identification of several cell surface proteins of non-T, non-B acute lymphoblastic leukemia by using monoclonal antibodies.J Immunol. 134 (2): 1276-85.2.Letarte, M.et al. (1993) Homotypic aggregation of pre-B leukemic cell lines by antibodies to VLA integrins correlates with their expression of CD9.Leukemia 7(1): 93-103.3.Hartz Bet al.(2011) α 4 integrin levels on mobilized peripheral blood stem cells predict rapidity of engraftment in patients receiving autologous stem cell transplantation.Blood. 118 (8): 2362-5.4.Ling, K.L.et al.(2007) Modulation of CD103 expression on human colon carcinoma-specific CTL.J Immunol. 178: 2908-15.

技术参数

产品应用 Flow

产品类型单克隆抗体

推荐用于 Flow

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Mouse anti Human CD49d monoclonal antibody, clone 44H6 BIO-RAD MCA923F Mouse anti Human CD49d monoclonal antibody, clone 44

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