mouse anti human HLA ABC:StarBright Violet 515

货号：MCA81SBV515

规格：100 Tests/0.5ml

市场价格：4055

产品类型：流式抗体

品牌：Bio-Rad

抗原：HLA ABC

物种：人

宿主：小鼠

抗体亚型：IgG2a

克隆号：W6/32

荧光染料：StarBright Violet 515

类型:	单抗	同型对照：	IgG2a
浓度：		用法：	5 µL/test(Flow)
免疫原性：	Purified human tonsil lymphocyte membranes.

Mouse anti Human HLA ABC antibody, clone W6/32recognizes an antigenic determinant shared among products of the HLA A, B and C loci. Clone W6/32 recognizes a conformational epitope, reacting with HLA class I alpha3 and alpha2 domains. The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In humans, this complex is referred to as the human leukocyte antigen (HLA) region. There are 3 major MHC class I proteins encoded by the HLA which are HLA A, HLA B and HLA C. These proteins are found on the surface of almost all nucleated somatic cells.Mouse anti Human HLA ABC antibody, clone W6/32 is routinely tested in flow cytometry on human peripheral blood lymphocytes.

数据

Figure A. Pacific Blue conjugated Mouse anti Human CD3 (MCA463PB). Figure B. Pacific Blue conjugated Mouse anti Human CD3 (MCA463PB) and SBV515 conjugated Mouse anti Human HLA ABC (MCA81SBV515). All experiments performed on red cell lysed human blood gated on live single cell lymphocytes, in the presence of 10% human serum. Data acquired on theZE5 Cell Analyzer.

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参考文献：

1. Zuo, J.et al.(2008) The DNase of gammaherpesviruses impairs recognition by virus-specific CD8+ T cells through an additional host shutoff function.J Virol. 82: 2385-93.2. Raftery, M.J.et al.(2002) Hantavirus infection of dendritic cells.J Virol. 76: 10724-33.3. Shi, J.et al.(2008) Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell-mediated lysis of myeloma.Blood. 111: 1309-17.4. Giuliani, F.et al.(2003) Vulnerability of human neurons to T cell-mediated cytotoxicity.J Immunol. 171: 368-79.5. Grotzke, J.E.et al.(2009) The Mycobacterium tuberculosis phagosome is a HLA-I processing competent organelle.PLoS Pathog. 5: e1000374.6. Koch, N.et al.(2009) IL-10 protects monocytes and macrophages from complement-mediated lysis.J Leukoc Biol. 86: 155-66.7. Smith, A.C.et al.(2005) Interaction of the Salmonella-containing vacuole with the endocytic recycling system.J Biol Chem. 280: 24634-41.8. Watling, D.et al.(2008) Multiple kinases in the interferon-gamma response.Proc Natl Acad Sci U S A. 105: 6051-6.9. Lask, A.et al.(2011) TCR-Independent Killing of B Cell Malignancies by Anti-Third-Party CTLs: The Critical Role of MHC-CD8 Engagement.J Immunol. 187: 2006-14.10. Barnstable, C.J.et al.(1978) Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis.Cell. 14 (1): 9-20.

技术参数

产品应用 Flow

产品类型 Monoclonal Antibody

推荐用于 Flow

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