Rat anti Mouse CD11b antibody, clone 5C6

货号：MCA711SBV515

规格：100 Tests/0.5ml

市场价格：3553

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：CD11b

物种：小鼠

宿主：大鼠

抗体亚型：IgG2b

克隆号：5C6

荧光染料：StarBright Violet 515

类型:	单抗	同型对照：	IgG2b
浓度：		用法：	5 µL/test(Flow)
免疫原性：	Thioglycollate-elicited peritoneal macrophages (TPM)

Rat anti Mouse CD11b antibody, clone 5C6recognizes CD11b, also known as the integrin alpha M chain. CD11b is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles.Rat anti Mouse CD11b antibody, clone 5C6 immunoprecipitates a heterodimer of ~165 and ~95 kDa. This clone also exhibits various functional properties, reportedly inhibiting adhesionin vitroand inflammatory recruitmentin vivo. Rat anti Mouse CD11b antibody, clone 5C6 also inhibits delayed hypersensitivity, potentiates bacterial infections and inhibits type 1 diabetes.

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参考文献：

1. Dohi, K.et al.(2010) Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury.J Neuroinflammation. 7: 41.2. Engwerda, C.R.et al.(2002) Locally up-regulated lymphotoxin alpha, not systemic tumor necrosis factor alpha, is the principle mediator of murine cerebral malaria.J Exp Med. 195: 1371-7.3. Heneka, M.T.et al.(2010) Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine.Proc Natl Acad Sci U S A. 107: 6058-63.4. Kim, D.et al.(2010) NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain.Proc Natl Acad Sci U S A. 107: 14851-6.5. Kondo, Y.et al.(2007) Osteopetrotic (op/op) mice have reduced microglia, no Abeta deposition, and no changes in dopaminergic neurons.J Neuroinflammation. 4: 31.6. Lesnik, P.et al.(2003) Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesis.J Clin Invest. 111: 333-40.7. Lin, H.H.et al.(2005) The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance.J Exp Med. 201: 1615-25.8. Mennini, T.et al.(2006) Nonhematopoietic erythropoietin derivatives prevent motoneuron degenerationin vitroandin vivo.Mol Med. 12: 153-60.9. Saura, J. (2007) Microglial cells in astroglial cultures: a cautionary note.J Neuroinflammation. 4: 26.10. Zwerina, K.et al.(2011) Vitamin D receptor regulates TNF-mediated arthritis.Ann Rheum Dis. 70:1122-9.

技术参数

产品应用 Flow

产品类型 Monoclonal Antibody

推荐用于 Flow

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