Mouse anti Human CDw328 antibody, clone 5-386 BIO-RAD MCA2522A647 Mouse anti Human CDw328 antibody, clone 5-386-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Mouse anti Human CDw328 antibody, clone 5-386 BIO-RAD MCA2522A647 Mouse anti Human CDw328 antibody, clone 5-386

2024-10-29

Mouse anti Human CDw328 antibody, clone 5-386

货号：MCA2522A647

规格：100 Tests/1ml

市场价格：3247

产品类型：流式抗体

品牌：Bio-Rad

抗原：CDw328

物种：人

宿主：小鼠

抗体亚型：IgG1

克隆号：5-386

荧光染料：Alexa Fluor 647

产品介绍
Mouse anti Human CDw328 antibody, clone 5-386recognizes human CDw328, a type I transmembrane glycoprotein and member of the Siglec (sialic acid binding Ig-like lectin) family, designated Siglec-7, originally identified as an inhibitory NK cell receptor (NKR) and negative regulator of NK activation, attributed to ITIM recruitment of SHP-1 phosphatase.CDw328 is expressed predominantly by natural killer cells (NK) and to a lesser extent by monocytes and granulocytes and, like Siglec-5 (CD170), has been shown to bind to sialylated ligands of targets through recognition of sialic acid in both the alpha-2,3- and alpha-2,6- glycosidic linkage.
产品详情
Target Species	Human
Product Form	Purified IgG conjugated to Alexa Fluor® 647 - liquid
Preparation	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution	Phosphate buffered saline
Immunogen	Human erythrocytes.
Preservative Stabilisers	0.09% Sodium Azide (NaN3)1% Bovine Serum Albumin
Fusion Partners	Spleen cells from immunised Balb/c mice were fused with cells of the X63-Ag8.653 myeloma cell line.
Approx. Protein Concentrations	IgG concentration 0.05 mg/ml
Max Ex/Em	Fluorophore	Excitation Max (nm)	Emission Max (nm)
Alexa Fluor®647	650	665
Acknowledgements	This product is provided under an intellectual property licence from Life Technologies Corporation. The transfer of this product is contingent on the buyer using the purchase product solely in research, excluding contract research or any fee for service research, and the buyer must not sell or otherwise transfer this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; (c) manufacturing or quality assurance or quality control, or (d) resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad CA 92008 USA or outlicensing@thermofisher.com
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light.
应用
Application Name	Verified	Min Dilution	Max Dilution
Flow Cytometry	√	Neat
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
文献
1.Izquierdo-useros, N.et al.(2012) Siglec-1 is a novel dendritic cell receptor that mediates HIV-1 trans-infection through recognition of viral membrane gangliosides.PLoS Biol. 10 (12): e1001448.2.Perez-Zsolt, D.et al.(2019) Anti-Siglec-1 antibodies block Ebola viral uptake and decrease cytoplasmic viral entry.Nat Microbiol. 4 (9): 1558-70

技术参数

产品应用 Flow

产品类型 Monoclonal Antibody

推荐用于 Flow

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Mouse anti Human CDw328 antibody, clone 5-386 BIO-RAD MCA2522A647 Mouse anti Human CDw328 antibody, clone 5-386

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