Rat anti mouse TREM-1 伯乐 Rat anti mouse TREM-1

2024-10-29

Rat anti mouse TREM-1

货号:MCA2578,MCA2578GA

规格:0.25 mg,0.1 mg

市场价格:3128,2210

产品类型:免疫组化一抗

品牌:Bio-Rad

抗原:TREM-1

物种:小鼠

宿主:大鼠

抗体亚型:IgG2a

克隆号:L5-B8.2A12.3A12

荧光染料:Purified

产品介绍
Rat anti Mouse Trem-1 antibody, clone L5-B8.2A12.3A12recognizes mouse triggering receptor expressed on myeloid cells 1 (TREM-1), a 30kD member of the immunoglobulin superfamily expressed on neutrophils and a subset of monocytes. TREM-1 is involved in the microbial inflammatory response. It acts in conjunction with the adaptor protein DAP12 to activate neutrophils and monocytes, leading to the secretion of pro-inflammatory mediators and enhancement of the inflammatory response. Microbial infection also induces the release of soluble form of TREM-1 from monocytes, which is reported to act as an inhibitor of TREM-1.TREM-1 mediates the septic shock pathway, and blocking TREM-1 has been reported to reduce inflammation and increase survival in certain models of bacterial infection.
产品详情
Target SpeciesMouse
Product FormPurified IgG - liquid
PreparationPurified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer SolutionPhosphate buffered saline
ImmunogenMouse TREM-1 Fc fusion protein.
Approx. Protein ConcentrationsIgG concentration 1.0mg/ml
Preservative Stabilisers0.09%Sodium Azide
Carrier FreeYes
RegulatoryFor research purposes only
Guarantee12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application NameVerifiedMin DilutionMax Dilution
Flow Cytometry1/25
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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文献
1.Wang, F.et al.(2012) Blocking TREM-1 signaling prolongs survival of mice withPseudomonas aeruginosainduced sepsis.Cell Immunol. 272 (2): 251-8.

技术参数

产品应用 Flow

产品类型 单克隆抗体

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