伯乐MCA1270A647 抗体mouse anti human CD13:Alexa Fluor® 647

货号：MCA1270A647,MCA1270A647T

规格：100 Tests/1ml,25 Tests/0.25ml

市场价格：3188,1420

产品类型：流式抗体

品牌：Bio-Rad

抗原：CD13

物种：人

宿主：小鼠

抗体亚型：IgG1

克隆号：WM15

荧光染料：Alexa Fluor 647

产品介绍

Mouse anti Human CD13 antibody, clone WM15recognizes human CD13 also known as aminopeptidase N. CD13 is a single pass type II glycosylated integral membrane protein with a predicted molecular mass of ~110 kDa and an apparent molecular mass of ~150 kDa expressed by granulocytes, monocytes, fibroblasts, endothelial cells and by myeloid leukaemia cells (Bradstocket al.1985). CD13 acts as a major cell surface receptor for group 1 coronoviruses (Breslinet al.2003) which bind to a critical sequence encompassing amino acid residies 288-295 (Kolbet al.1997).CD13 functions as anaminopeptidaseenzyme, a metalloprotease present as both a membrane bound form and also a soluble aminopeptidase N.Mouse anti Human CD13, clone WM15 inhibits infection of cells by human coronavirus (Lachanceet al.1998) but not hepatitis C virus (Koutsoudakiset al.2006) and inhibits aminopeptidase N activity of the CD13 molecule (Asmunet al.1992).

Figure A. FITC conjugated mouse anti human CD11b (MCA551F) and Alexa647® conjugated Mouse IgG1 isotype control (MCA928A647). Figure B. FITC conjugated mouse anti human CD11b (MCA551F) and Alexa647® conjugated mouse anti human CD13 (MCA1270A647). All experiments performed on red cell lysed Human peripheral blood gated on all mononuclear cells in the presence of Human SeroBlock (BUF070A).