mouse anti human CD14:StarBright Violet 440

货号：MCA1568SBV440

规格：100 Tests/0.5ml

市场价格：3808

产品类型：流式抗体

品牌：Bio-Rad

物种：人

宿主：小鼠

抗体亚型：其它

荧光染料：其它

类型：	单抗	同型对照：	IgG2a
浓度：		用法：	5.0 µL/test(Flow)
免疫原性：

Mouse anti human CD14 antibody, clone TÜK4recognizes the human CD14 cell surface antigen. CD14 is a ~55 kDa glycoprotein that contains multiple leucine-rich repeats. It is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) linkage (Simmonset al.1989), a soluble form of CD14 also exists (Bazilet al.1986).CD14 is strongly expressed on the surface of monocytes and macrophages but has also been shown to be expressed on the surface of non-myeloid cells (Jersmann 2005). CD14 functions as a pattern recognition receptor (Puginet al.1994,Dziarskiet al.1998) in innate immunity for a variety of ligands, in particular for the LPS (endotoxin) of Gram-negative bacteria.Mouse anti human CD14 antibody, clone TÜK4 has been shown to block SDF-induced chemotaxis of U937 cells in a dose –dependent manner (Yanget al.2003). Use of theanti-human CD14 antibody, Low Endotoxin formatis recommended for this purpose.

数据：

Figure A. FITC conjugated Mouse anti Human CD63 (MCA2142F). Figure B. FITC conjugated Mouse anti Human CD63 (MCA2142F) and StarBright Violet 440 conjugated Mouse anti Human CD14 (MCA1568SBV440). All experiments performed on human blood gated on live single mononuclear cells, in the presence of 10% human serum. Data acquired on the ZE5 Cell Analyzer.

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参考文献：

1.Schenk, M.et al.(2005) Macrophages expressing triggering receptor expressed on myeloid cells-1 are underrepresented in the human intestine.J Immunol. 174 (1): 517-24.2.Willett, B.J.et al.(2003) Expression of CXCR4 on feline peripheral blood mononuclear cells: effect of feline immunodeficiency virus infection.J Virol. 77 (1): 709-12.3.Soell, M.et al.(1995) Activation of human monocytes by streptococcal rhamnose glucose polymers is mediated by CD14 antigen, and mannan binding protein inhibits TNF-alpha release.J Immunol. 154 (2): 851-60.4.Bryan, S.A.et al.(2002) Responses of leukocytes to chemokines in whole blood and their antagonism by novel CC-chemokine receptor 3 antagonists.Am J Respir Crit Care Med. 165: 1602-9.5.Weiss, D.J. (2001) Evaluation of proliferative disorders in canine bone marrow by use of flow cytometric scatter plots and monoclonal antibodies.Vet Pathol. 38: 512-8.6.Gupta, V.K.et al.(1996) Identification of the sheep homologue of the monocyte cell surface molecule--CD14.Vet Immunol Immunopathol. 51 (1-2): 89-99.7.Sopp, P. & Howard, C.J. (1997) Cross-reactivity of monoclonal antibodies to defined human leucocyte differentiation antigens with bovine cells.Vet Immunol Immunopathol. 56 (1-2): 11-25.8.Xiong, W.et al.(2010) Human Flt3L generates dendritic cells from canine peripheral blood precursors: implications for a dog glioma clinical trial.PLoS One. 5: e11074.9.Werling, D.et al.(1998) Analysis of the phenotype and phagocytic activity of monocytes/macrophages from cattle infected with the bovine leukaemia virus.Vet Immunol Immunopathol. 62 (3): 185-95.10.Yang, H.et al.(2003) Antibody to CD14 like CXCR4-specific antibody 12G5 could inhibit CXCR4-dependent chemotaxis and HIV Env-mediated cell fusion.Immunol Lett. 88 (1): 27-30.

技术参数

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