BIO-RAD MCA5964GA Mouse anti Human interleukin-11, clone C01-1C2,Mouse anti Human interleukin-11, clone C01-1C2-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

BIO-RAD MCA5964GA Mouse anti Human interleukin-11, clone C01-1C2,Mouse anti Human interleukin-11, clone C01-1C2

2024-10-22

Mouse anti Human interleukin-11, clone C01-1C2

货号：MCA5964GA

规格：0.1 mg

价格：2576

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：interleukin-11

物种：人

宿主：小鼠

抗体亚型：IgG1

克隆号：C01-1C2

荧光染料：Purified

产品介绍
Mouse anti Human interleukin-11, clone C01-1C2,recognizes human interleukin-11 (IL-11), a 178 amino acid non-glycosylated pleiotropic cytokine, also known as AGIF. IL-11 is a 19 kDa member of the IL-6 of cytokines. It signals through a high affinity receptor complex, made up of the IL-11 receptor alpha chain (IL-11Ralpha) and gp130 which triggers homo- or hetero-dimerization of gp130. Although gp130 and its dimer partners possess no kinase activity, the dimerization of gp130 leads to activation of tyrosine kinases and modulation of transcriptional activity.IL-11 is an important regulator in the haematopoiesis of erythroid, myeloid and megakaryocyte progenitor cells and is expressed in a variety of tissues including the lung, bone, thymus and connective tissue. Expression of IL-11 in endometrial stromal cells is vital for normal murine embryo development, and implicated in decidualization during human pregnancy. IL-11 is a functionally diverse signalling molecule with roles in megakaryopoiesis (Dams-Kozlowskaet al.2013), bone growth (Simset al.2005) and T cell proliferation (Curtiet al.2002).
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
Preparation	Purified IgG prepared by affinity chromatography on Protein G from ascites
Buffer Solution	Phosphate buffered saline
Immunogen	E. coliderived recombinant protein corresponding to aa 23-125 of human IL-11
Fusion Partners	Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Preservative Stabilisers	0.1% Sodium Azide (NaN3)0.1% Bovine Serum Albumin
Approx. Protein Concentrations	IgG concentration 1.0 mg/ml
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
ELISA	√
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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文献
1.Curti, A.et al.(2002) Interleukin-11 induces proliferation of human T-cells and its activity is associated with downregulation of p27(kip1)Haematologica 87: 373-80.2.Dams-kozlowska, H.et al.(2013) Designer cytokine hyper interleukin 11 (H11) is a megakaryopoietic factor.Int J Med Sci. 10 (9): 1157-65.3.Sims, N.A.et al.(2005) Interleukin-11 receptor signaling is required for normal bone remodelingJournal of Bone and Mineral Research 20: 1093–102.

技术参数

产品应用 Elisa

产品类型 Monoclonal Antibody

推荐用于 Elisa

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BIO-RAD MCA5964GA Mouse anti Human interleukin-11, clone C01-1C2,Mouse anti Human interleukin-11, clone C01-1C2

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