Rat anti Mouse F4/80:StarBright Violet 670

货号：MCA497SBV670

规格：100 Tests/0.5ml

价格：4063

产品类型：流式抗体

品牌：Bio-Rad

抗原：F4/80

物种：小鼠

宿主：大鼠

抗体亚型：IgG2b

克隆号：Cl:A3-1

荧光染料：StarBright Violet 670

类型:	单抗	同型对照：	IgG2b
浓度：		用法：	5 µL/test(Flow)
免疫原性：	Thioglycollate stimulated peritoneal macrophages from C57BL/6 mice.

Rat anti Mouse F4/80 antibody, clone A3-1recognizes themurine F4/80 antigen, a ~160 kDa cell surface glycoprotein member of the EGF-TM7 family of proteins which shares 68% overall amino acid identity with human EGF module-containing mucin-like hormone receptor 1 (EMR1).Expression of F4/80 is heterogeneous and is modulated during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans cells, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen (Hume,et al.1984). F4/80 antigen is also expressed on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node (Gordon,et al.1994). The ligands and biological functions of the F4/80 antigen have not been fully determined but a role for F4/80 in the generation of efferent CD8+ve regulatory T cells is proposed (Lin,et al.2005)Rat anti mouse F4/80 antibody, clone Cl:A3-1 modulates cytokine levels released in response toListeria monocytogenes(Warschkau & Kiderlen, 1999).A Human anti-idiotypic CI:A31 antibody, clone 17867 (HCA154) which binds to and blocks activity of Rat anti mouse F4/80 antibody, clone Cl:A3-1 is also available for use as a control in experiments utilizing clone A3-1.

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参考文献：

1. Zumsteg, A.et al.(2009) Myeloid cells contribute to tumor lymphangiogenesis.PLoS One. 4:e7067.2. Sun, G.et al.(2011) RIP2-mediated LKB1 deletion causes axon degeneration in the spinal cord and hind-limb paralysis.Dis Model Mech. 4: 193-202.3. Amano, H.et al.(2005) Absence of recipient CCR5 promotes early and increased allospecific antibody responses to cardiac allografts.J Immunol. 174: 6499-508.4. Anatelli, F.et al.(2006) Macrophage-targeted photosensitizer conjugate delivered by intratumoral injection.Mol Pharm. 3: 654-64.5. Anghelina, M.et al.(2006) Monocytes/macrophages cooperate with progenitor cells during neovascularization and tissue repair: conversion of cell columns into fibrovascular bundles.Am J Pathol. 168: 529-41.6. Baratta, J.L.et al.(2009) Cellular organization of normal mouse liver: a histological, quantitative immunocytochemical, and fine structural analysis.Histochem Cell Biol. 131: 713-26.7. Baudy, A.R.et al.(2011) Non-invasive optical imaging of muscle pathology in mdx mice using cathepsin caged near-infrared imaging.Mol Imaging Biol. 13: 462-70.8. Bevaart, L.et al.(2004) CpG oligodeoxynucleotides enhance FcgammaRI-mediated cross presentation by dendritic cells.Int Immunol. 16: 1091-8.9. Biffi, A.et al.(2004) Correction of metachromatic leukodystrophy in the mouse model by transplantation of genetically modified hematopoietic stem cells.J Clin Invest. 113: 1118-29.10. Brown, G.D.et al.(2002) Dectin-1 is a major beta-glucan receptor on macrophages.J Exp Med. 196: 407-12.

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