mouse anti human HLA DP DQ DR:StarBright Violet 440

货号：MCA477SBV440

规格：100 Tests/0.5ml

价格：3808

产品类型：流式抗体

品牌：Bio-Rad

抗原： HLA DP DQ DR

物种：人

宿主：小鼠

抗体亚型：IgG2a, kappa

克隆号：WR18

荧光染料：其它

类型:	单抗	同型对照：	IgG2a
浓度：		用法：	5 µL/test(Flow)
免疫原性：	Human HLA Class II (DP, DQ, DR).

Mouse anti Human HLA DP DQ DR antibody, clone WR18reacts with a monomorphic determinant common to DP, DQ and DR beta chains, which are expressed by antigen presenting cells, B cells, monocytes and activated T lymphocytes.The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In humans, this complex is referred to as the human leukocyte antigen (HLA) region. There are 3 major MHC class II proteins encoded by the HLA which are HLA DP, HLA DQ and HLA DR.

数据

Figure A. Alexa Fluor 488 conjugated Mouse anti Human CD19 (MCA1940A488). Figure B. Alexa Fluor 488 conjugated Mouse anti Human CD19 (MCA1940A488) and SBV440 conjugated Mouse anti Human HLA DP DQ DR (MCA477SBV440). All experiments performed on red cell lysed human blood gated on live single lymphocytes, in the presence of 10% human serum. Data acquired on the ZE5 Cell Analyzer.

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参考文献：

1. Moore, K.et al. (1987) Use of the monoclonal antibody WR17, identifying the CD37 gp40-45 Kd antigen complex, in the diagnosis of B-lymphoid malignancy.J Pathol 152:13-21.2. Kissner, T.L.et al.(2011) Activation of MyD88 Signaling upon Staphylococcal Enterotoxin Binding to MHC Class II Molecules.PLoS One. 6: e15985.3. Chia, J.S.et al.(2001) Human T-cell responses to the glucosyltransferases ofStreptococcus mutans.Clin Diagn Lab Immunol. 8: 441-5.4. Chang, Y.C.et al.(2008) Epigenetic control of MHC class II expression in tumor-associated macrophages by decoy receptor 3.Blood. 111: 5054-63.5. Litzinger, M.T.et al.(2009) Chronic lymphocytic leukemia (CLL) cells genetically modified to express B7-1, ICAM-1, and LFA-3 confer APC capacity to T cells from CLL patients.Cancer Immunol Immunother. 58: 955-65.6. Sadallah, S.et al.(2011) Microparticles (ectosomes) shed by stored human platelets downregulate macrophages and modify the development of dendritic cells.J Immunol. 186: 6543-52.7. Sabbah, S.et al.(2012) T-cell immunity to Kaposi sarcoma-associated herpesvirus: recognition of primary effusion lymphoma by LANA-specific CD4+ T cells.Blood. 119 (9): 2083-92.8. John, J.et al.(2010) Differential effects of Paclitaxel on dendritic cell function.BMC Immunol. 11:14.9. Palmer, K.J.et al.(2000) Interferon-alpha (IFN-alpha) stimulates anti-melanoma cytotoxic T lymphocyte (CTL) generation in mixed lymphocyte tumour cultures (MLTC).Clin Exp Immunol. 119: 412-8.10. Silk, K.M.et al.(2012) Rapamycin conditioning of dendritic cells differentiated from human ES cells promotes a tolerogenic phenotype.J Biomed Biotechnol. 2012: 172420.

技术参数

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