BIO-RAD MCA2756 Mouse anti Human CD154 (Soluble) antibody, clone 2A3,Mouse anti Human CD154 (Soluble) antibody, clone 2A3-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

BIO-RAD MCA2756 Mouse anti Human CD154 (Soluble) antibody, clone 2A3,Mouse anti Human CD154 (Soluble) antibody, clone 2A3

2024-10-22

Mouse anti Human CD154 (Soluble) antibody, clone 2A3

货号：MCA2756

规格：0.2 mg

价格：3375

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：CD154 (Soluble)

物种：人

宿主：小鼠

抗体亚型：IgG1

克隆号：2A3

荧光染料：Purified

产品介绍
Mouse anti Human CD154 (Soluble) antibody, clone 2A3recognizes the soluble form of CD154, otherwise known as CD40 Ligand/TRAP, a ~32 kDa glycoprotein and member of the TNF family, which is specifically expressed on activated, but not resting, CD4+ T cells, dendritic cells (DCs), B cells and macrophages.CD154 binds CD40, and acts as a key co-stimulatory molecule through the activation of antigen-presenting cells, and as a regulator of the generation and functional properties of Th1 helper cells. CD154 exists in both a membrane-bound and soluble form, the latter of which is generated through proteolytic processing by a matrix metalloproteinase (MMP), in activated cells.The binding of CD154 with its receptor CD40 is vital for many biological processes, including Ig class switching, germinal centre formation and the survival of CD40+ B cells, B cell proliferation in the absence of co-stimulus, the production of IgE in the presence of interleukin-4 (IL-4), and also in the production of pro-inflammatory cytokines, MMPs, prostaglandins and adhesion molecule upregulation, in non-immune cells.Mouse anti Human CD154 (Soluble) antibody, clone 2A3recognizes the soluble form of the protein.
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
Preparation	Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Buffer Solution	Phosphate buffered saline
Immunogen	Recombinant human soluble CD154 conjugated to BSA.
Fusion Partners	Spleen cells from immunised Balb/c mice were fused with cells of the myeloma Sp2/0 cell line.
Preservative Stabilisers	<0.1% Sodium Azide (NaN3)
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
ELISA	√
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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文献
1.Pietravalle, F.et al.(1996) Human native soluble CD40L is a biologically active trimer, processed inside microsomes.J Biol Chem. 271 (11): 5965-7.

技术参数

产品应用 Elisa;WB

产品类型 Monoclonal Antibody

推荐用于 Elisa;WB

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BIO-RAD MCA2756 Mouse anti Human CD154 (Soluble) antibody, clone 2A3,Mouse anti Human CD154 (Soluble) antibody, clone 2A3

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