BIO-RAD MCA2734GA Mouse anti Human MMP-3 antibody, clone 1B4 ,Mouse anti Human MMP-3 antibody, clone 1B4-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

BIO-RAD MCA2734GA Mouse anti Human MMP-3 antibody, clone 1B4 ,Mouse anti Human MMP-3 antibody, clone 1B4

2024-10-22

Mouse anti Human MMP-3 antibody, clone 1B4

货号：MCA2734GA

规格：0.1 mg

价格：2550

产品类型：免疫组化一抗

品牌：Bio-Rad

物种：人

宿主：小鼠

抗体亚型：IgG1

克隆号：1B4

荧光染料：Purified

产品介绍
Mouse anti Human MMP-3 antibody, clone 1B4recognizes human matrix metalloproteinase 3, also known as MMP-3, stromelysin-1 or transin-1. MMP-3 in its pro-form is a 477 amino acid ~54kDa zinc dependent endopeptidase processed to a 378 amino acid, ~45 kDa peptide in the mature form containing 4hemopexin-likerepeats.MMPs are also involved in cell proliferation, migration, differentiation and apoptosis (Janaet al.2012). Most MMP’s are synthesised as inactive zymogens and a propeptide region must be cleaved off before the enzyme becomes active. Their expression is increased dramatically in a variety of cancer types, where it indicates invasive disease and a poor prognosis (Holmberget al.2013). MMP-3 can degrade proteoglycan, fibronectin, laminin, and type IV collagen, but not interstitial type I collagen (Wilhelmet al.1993). It can activate other MMP’s and may be involved in the repair processes of the heart after myocardial infarction (Wanget al.2011).Mouse anti human MMP-3 antibody, clone 1B4 has been used successfully for the identification of MMP-3 in gastric cancer by both Western blotting and immunohistochemistry (Murrayet al.1998)
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
Preparation	Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution	Phosphate buffered saline
Immunogen	Ovalbumin conjugated synthetic peptide corresponding to a region within the C-terminus of human MMP-3.
Fusion Partners	Spleen cells from immunised Balb/c mice were fused with cells of the Ag8563 myeloma cell line.
Preservative Stabilisers	<0.1% Sodium Azide (NaN3)
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
Flow Cytometry	√	1/50
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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文献
1.Murray, G.I.et al.(1998) Matrix metalloproteinases and their inhibitors in gastric cancer.Gut. 43 (6): 791-7.2.Lyall, M.S.et al.(2006) Profiling markers of prognosis in colorectal cancer.Clin Cancer Res. 12 (4): 1184-91.3.Juica, N.E.et al.(2017)Neisseria gonorrhoeaeChallenge Increases Matrix Metalloproteinase-8 Expression in Fallopian Tube Explants.Front Cell Infect Microbiol. 7: 399.

技术参数

产品应用 Elisa;WB

产品类型 Monoclonal Antibody

推荐用于 Elisa;WB

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BIO-RAD MCA2734GA Mouse anti Human MMP-3 antibody, clone 1B4 ,Mouse anti Human MMP-3 antibody, clone 1B4

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