BIO-RAD MCA2736GA Mouse anti Human MMP-9 Activated antibody, clone 4A3,Mouse anti Human MMP-9 Activated antibody, clone 4A3-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

BIO-RAD MCA2736GA Mouse anti Human MMP-9 Activated antibody, clone 4A3,Mouse anti Human MMP-9 Activated antibody, clone 4A3

2024-10-22

Mouse anti Human MMP-9 Activated antibody, clone 4A3

货号：MCA2736GA,MCA2736

规格：0.1 mg,0.2 mg

价格：3868,6630

产品类型：免疫组化一抗

品牌：Bio-Rad

物种：人

宿主：小鼠

抗体亚型：IgG1

克隆号：4A3

荧光染料：Purified

产品介绍
Mouse anti Human MMP-9 Activated antibody, clone 4A3recognizes the active form of human matrix metalloproteinase 9 (MMP-9). The MMP’s are zinc-dependent endopeptidases responsible for degrading the extracellular matrix. They are also involved in cell proliferation, migration, differentiation and apoptosis. Most MMP’s are synthesised as inactive zymogens and a propeptide region must be cleaved off before the enzyme becomes active. Their expression is increased dramatically in a variety of cancer types, where it indicates invasive disease and a poor prognosis. MMP-9 is a gelatinase, cleaving type IV collagen and gelatin. The gelatinases have an additional gelatin-binding domain inserted in the catalytic domain. MMP-9, alongside other MMPs, plays a role in normal tissue remodeling such as embryonic development, ovulation, mammary gland involution and wound healing. It is important in the early stages of tumor invasion as it degrades the type IV collagen in the basement membrane.Mouse anti Human MMP-9 Activated antibody, clone 4A3 recognizes only the active form of MMP-9. It does not react with the MMP-9 proenzyme or the active or proenzyme forms of MMP-2.
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
Preparation	Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution	Phosphate buffered saline
Immunogen	Ovalbumin conjugated synthetic peptide corresponding to a region within the N-terminus of human MMP-9.
Fusion Partners	Spleen cells from immunised Balb/c mice were fused with cells of the Ag8563 myeloma cell line.
Preservative Stabilisers	Pack Size: 0.2 mg0.09% Sodium Azide (NaN3)Pack Size: 0.1 mg<0.1% Sodium Azide (NaN3)
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
Flow Cytometry	√	1/50
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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文献
1.Duncan, M.E.et al.(1998) Human matrix metalloproteinase-9: activation by limited trypsin treatment and generation of monoclonal antibodies specific for the activated form.Eur J Biochem. 258 (1): 37-43.2.Šelemetjev Set al.(2016) Coexpressed High Levels of VEGF-C and Active MMP-9 Are Associated With Lymphatic Spreading and Local Invasiveness of Papillary Thyroid Carcinoma.Am J Clin Pathol. Nov 2. pii: aqw184. [Epub ahead of print]3.Dede, E.et al.(2021) The effects of exercise training on cardiac matrix metalloproteinases activity and cardiac function in mice with diabetic cardiomyopathyBiochem Biophys Res Comm. 09 Nov [Epub ahead of print].

技术参数

产品应用 WB

产品类型 Monoclonal Antibody

推荐用于 WB

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BIO-RAD MCA2736GA Mouse anti Human MMP-9 Activated antibody, clone 4A3,Mouse anti Human MMP-9 Activated antibody, clone 4A3

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