Rat anti mouse Ly-6C:StarBright Violet 610

货号：MCA2389SBV610

规格：100 Tests/0.5ml

价格：3885

产品类型：抗体和ELISA

品牌：Bio-Rad

类型：	单抗	同型对照：	IgG2a
浓度：		用法：	5.0 µL/test(Flow)
免疫原性：	Balb/c macrophage precursor cell hybrids.

Rat anti Mouse Ly-6C antibody, clone ER-MP20recognizes murine Ly-6C, a 131 amino acid ~14 kDa differentiation antigen, expressed on macrophage/dendritic cell precursors in mid-stage development (late CFU-M, monoblasts and immature monocytes), granulocytes, and on a wide range of endothelial cells and subpopulations of B- and T-lymphocytes.Rat anti Mouse Ly-6C antibody, clone ER-MP20 is able to distinguish multiple mouse blood monocyte subsets: immature Ly-6Chimonocytes are recruited to acute peripheral inflammation and develop into Ly-6C+exudate macrophages, whereas more mature Ly-6C-/lomonocytes are precursors for tissue macrophages and dendritic cells in steady state.Rat anti Mouse Ly-6C, clone ER-MP20 can be used in conjunction with cloneER-MP12in two colour flow cytometric analysis, to identify different stages of myeloid progenitor cells in mouse bone marrow (Leenenet al.1990).Rat anti Mouse Ly-6C was originally described as recognizing a protein encoded by the LY6C gene. It has subsequently become apparent that the LY6C locus demonstrates polymorphism and the LY6C gene has been re-designatedLY6C2. TheLY6C1gene encodes a similar protein with ~95% sequence homology to LY6C2.

数据：

Figure A. StarBright Blue 700 conjugated Rat anti Mouse CD3 (MCA500SBB700). Figure B. StarBright Blue 700 conjugated Rat anti Mouse CD3 (MCA500SBB700) and StarBright Violet 610 conjugated Rat anti Mouse Ly6C (MCA2389SBV610). All experiments performed on red blood lysed mouse blood gated on live single cell lymphocytes, in the presence of 10% mouse serum. Data acquired on the ZE5 Cell Analyzer.

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参考文献：

1.Zhang, Y. & Bliska, J.B. (2010) YopJ-promoted cytotoxicity and systemic colonization are associated with high levels of murine interleukin-18, gamma interferon, and neutrophils in a live vaccine model ofYersinia pseudotuberculosisinfection.Infect Immun 78: 2329-41.2.Leenen, P.J.et al.(1990) Murine macrophage precursor characterization. II. Monoclonal antibodies against macrophage precursor antigens.Eur J Immunol. 20 (1): 27-34.3.de Bruijn, M.F.et al.(1998) Bone marrow cellular composition in Listeria monocytogenes infected mice detected using ER-MP12 and ER-MP20 antibodies: a flow cytometric alternative to differential counting.J Immunol Methods. 217 (1-2): 27-39.4.Schatteman, G.C.et al.(2010) Lin- Cells Mediate Tissue Repair by Regulating MCP-1/CCL-2.Am J Pathol. 177: 2002-10.5.Baumeister, T.et al.(2003) Interleukin-3Ralpha+ myeloid dendritic cells and mast cells develop simultaneously from different bone marrow precursors in cultures with interleukin-3.J Invest Dermatol. 121: 280-8.6.Devey, L.et al.(2009) Tissue-resident macrophages protect the liver from ischemia reperfusion injury via a heme oxygenase-1-dependent mechanism.Mol Ther. 17: 65-72.7.Nikolic, T.et al.(2003) Developmental stages of myeloid dendritic cells in mouse bone marrow.Int Immunol. 15: 515-24.8.Wynn, A.A.et al.(2001) Role of granulocyte/macrophage colony-stimulating factor in zymocel-induced hepatic granuloma formation.Am J Pathol. 158 (1): 131-45.9.Lesokhin, A.M.et al.(2012) Monocytic CCR2+ Myeloid-Derived Suppressor Cells Promote Immune Escape by Limiting Activated CD8 T-cell Infiltration into the Tumor Microenvironment.Cancer Res. 72: 876-86.10.Chan, J.et al.(1998) Macrophage lineage cells in inflammation: characterization by colony-stimulating factor-1 (CSF-1) receptor (c-Fms), ER-MP58, and ER-MP20 (Ly-6C) expression.Blood. 92: 1423-31.

技术参数

产品应用 Flow

产品类型 单克隆抗体

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