Bio-Rad MCA1824EL CD89抗体,mouse anti human CD89:Low Endotoxin-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Bio-Rad MCA1824EL CD89抗体,mouse anti human CD89:Low Endotoxin

2024-10-22

mouse anti human CD89:Low Endotoxin

货号：MCA1824EL

规格：0.5 mg

价格：7200

产品类型：流式抗体

品牌：Bio-Rad

抗原： CD89

物种：人

宿主：小鼠

抗体亚型：IgG1, kappa

克隆号：MIP8a

荧光染料：其它

产品介绍
Mouse anti Human CD89 antibody, clone MIP8arecognizes the human CD89 cell surface antigen, a 50-75 kDa cell surface glycoprotein that is also known as the IgA receptor (Fc alpha R).CD89 is expressed by peripheral blood monocytes and neutrophils.MIP8a blocks binding of IgA to the Fc alpha R, and also inhibits neutrophil phagocytosis of IgA complexes.
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
BufferSolution	Phosphate buffered saline
Preservative Stabilisers	None present
Immunogen	Recombinant soluble human Fc alpha R.
Fusion Partners	Lymph node cells from immunised Armenian hamsters were fused with cells of the mouse X63-Ag8.653 myeloma cell line.
Approx. Protein Concentrations	IgG concentration 1.0 mg/ml
Endotoxin Level	< 0.01 EU/ug
Regulatory	For research purposes only
Guarantee	12 monthsfrom date of despatch
存储条件
Store at -20oC only.This product should be stored undiluted.Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
应用
Application Name	Verified	Min Dilution	Max Dilution
Flow Cytometry	√	1/50	1/100
ELISA	√
Immunoprecipitation	√
Functional Assays	√
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewedpublications or personal communications fromthe originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. Flow CytometryUse 10ul of the suggested working dilution to label 106cells or 100ul whole blood
数据
Staining of human peripheral blood granulocytes with low endotoxin Mouse anti Human CD89 antibody (MCA1824EL).
同型
Description	Product Code	Applications	Pack Size
Mouse IgG1 Negative Control:Low Endotoxin	MCA928EL	F	0.5 mg
文献
1. Hamre, R.et al.(2003) Expression and modulation of the human immunoglobulin A Fc receptor (CD89) and the FcR gamma chain on myeloid cells in blood and tissue.Scand J Immunol. 57: 506-16.2. Qian,K.et al.(2008) Functional expression of IgA receptor FcalphaRI on human platelets.J Leukoc Biol. 84: 1492-500.3. Van Egmond, M. (2011) Method for the treatment or prophylaxis of chronic inflammatory diseases.European Patent Application No: 12/7369634. Pascal, V.et al.(2012) Anti-CD20 IgA can protect mice against lymphoma development: evaluation of the direct impact of IgA and cytotoxic effector recruitment on CD20 target cells.Haematologica. 97 (11): 1686-94.5. Mladenov, R.et al.(2015) The Fc-alpha receptor is a new target antigen for immunotherapy of myeloid leukemia.Int J Cancer. 137 (11): 2729-38.6. Aleyd, E.et al.(2016) IgA Complexes in Plasma and Synovial Fluid of Patients with Rheumatoid Arthritis Induce Neutrophil Extracellular Traps via FcαRI.J Immunol. 197 (12): 4552-9.7. van der Steen, L.et al.(2009) Immunoglobulin A: Fc(alpha)RI interactions induce neutrophil migration through release of leukotriene B4.Gastroenterology. 137 (6): 2018-29.e1-3.8. Hamre, R.et al.(2003) Expression and modulation of the human immunoglobulin A Fc receptor (CD89) and the FcR gamma chain on myeloid cells in blood and tissue.Scand J Immunol. 57 (6): 506-16.9. Lu, J.et al.(2014) Pentraxins and IgA share a binding hot-spot on FcαRI.Protein Sci. 23 (4): 378-86.10. Askarian, F.et al.(2021) The lytic polysaccharide monooxygenase CbpD promotesPseudomonas aeruginosa.virulence in systemic infection.Nat Commun. 12 (1): 1230.

技术参数

产品应用 ELISA; Flow； FN ;IP

产品类型 Monoclonal Antibody

推荐用于 ELISA; Flow； FN ;IP

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Bio-Rad MCA1824EL CD89抗体,mouse anti human CD89:Low Endotoxin

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