BIO-RAD MCA1799T Mouse anti Human Estrogen Receptor Alpha,Mouse anti Human Estrogen Receptor Alpha-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

BIO-RAD MCA1799T Mouse anti Human Estrogen Receptor Alpha,Mouse anti Human Estrogen Receptor Alpha

2024-10-22

Mouse anti Human Estrogen Receptor Alpha

货号：MCA1799T,MCA1799

规格：0.1 ml,1ml

价格：1505,14306

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：Estrogen Receptor Alpha

物种：人

宿主：小鼠

抗体亚型：IgG1

克隆号：6F11

荧光染料：Purified

产品介绍
Mouse anti Human estrogen alpha antibody, clone 6F11recognizes the human estrogen receptor alpha chain (ERα), also known as the estradiol receptor or nuclear receptor subfamily 3 group A member 1. ERα is a ~65 kDa steroid hormone receptor containing an N-terminal (AF-1) ligand independent transactivation domain, a DNA binding domain and a C-terminal ligand binding domain which overlaps with an (AF-2) domain. ERα binds to DNA as a homodimer (Klinge 2001) and can also form heterodimers with Estrogen receptor beta.The detection of estrogen (ER) and progesterone (PR) receptors using immunohistochemical staining of formalin fixed, paraffin embedded (FFPE) tissue, has gradually replaced ligand binding assays, to become the most common method for the determination of the ER/PR status of breast tumors (Yazijiet al.2008). Approximately 75% to 80% of breast tumors have estrogen and/or progesterone receptors, and the presence of these receptors helps determine both the patients prognosis and the effectiveness of hormonal therapy (Bhargavaet al.2012).Mouse anti human estrogen alpha antibody, clone 6F11 has been used successfully for identification of ERα on breast cancer cell lysates using Western blotting and for the immunohistochemical detection of ERα in breast cancer tissues (Ambroiseet al.2011).
产品详情
Target Species	Human
Product Form	Tissue Culture Supernatant - liquid
Species Cross-Reactivity	Target Species	Cross Reactivity
Human	√
Dog	√
nPreparatio	Recombinant human estrogen receptor (alpha form).
Buffer Solution	Phosphate buffered saline
Preservative Stabilisers	Pack Size: 1 mlPack Size: 0.1 ml<0.1% Sodium Azide (NaN3)
Approx. Protein Concentrations	IgG concentration 1.0 mg/ml
Fusion Partners	Spleen cells from immunised mice were fused with cells of the mouse p3-NS1-Ag4-1 myeloma cell line.
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light.
应用
Application Name	Verified	Min Dilution	Max Dilution
Immunohistology - Frozen1	√	1/40
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
推荐产品
Description	Product Code	Applications	Pack Size
Goat anti Mouse IgG (H/L):Alk. Phos. (Multi Species Adsorbed)	STAR117A	F	0.5mg
文献
1.Bevitt, D.J.et al.(1997) New monoclonal antibodies to oestrogen and progesterone receptorective for paraffin section immunohistochemistry.J Pathol. 183 (2): 228-32.2.Jongen, V.et al.(2009) Expression of estrogen receptor-alpha and -beta and progesterone receptor-A and -B in a large cohort of patients with endometrioid endometrial cancer.Gynecol Oncol. 112: 537-42.3.Ambroise, M.et al.(2011) Immunohistochemical profile of breast cancer patients at a tertiary care hospital in South India.Asian Pac J Cancer Prev. 12: 625-9.

技术参数

产品应用 WB

产品类型 Monoclonal Antibody

推荐用于 WB

© bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪是专业的授权总代理区域代理经销平台。
© 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
© 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
© 本文地址：https://gibcohyclone.cn/thread-40134.htm

特别声明：以上内容(如有图片亦包括在内)来源于授权厂家或网络，如有侵权，请联系删除，本平台不提供信息存储服务。

Notice: The content above (including the pictures if any)comes from authorized manufacturers or networks. In case of infringement, please contact to delete it. This platform does not provide information storage services.

产品询价需求提交

BIO-RAD MCA1799T Mouse anti Human Estrogen Receptor Alpha,Mouse anti Human Estrogen Receptor Alpha

相关推荐