BIO-RAD MCA1788A488 Rat anti Human HER2/neu:Alexa Fluor®488,Rat anti Human HER2/neu:Alexa Fluor®488

2024-10-22

Rat anti Human HER2/neu:Alexa Fluor®488

货号:MCA1788A488

规格:100 Tests/1ml

价格:2533

产品类型:流式抗体

品牌:Bio-Rad

抗原:HER2/neu

物种:人

宿主:大鼠

抗体亚型:IgG2a

克隆号:ICR55

荧光染料:Alexa Fluor 488

产品介绍
Rat anti Human HER2/neu antibody, clone ICR55recognizes epitope E of human HER2/neu, otherwise known as CD340 and c-ErbB-2, a proto-oncogene expressed at the cell surface of a range of tumor cells, often associated with poor prognosis, and an increased risk of metastasis.HER2/neu is used in conjunction with antibodies recognizing both Estrogen and Progesterone receptors, for the classification of breast cancer tumors, and to determine patient prognosis and course of treatment.Excessive HER2/neu is present in around 20% to 25% of invasive breast cancers, referred to as HER2-positive cancer, and can help determine whether drugs such as trastuzumab (Herceptin) or lapatinib (Tykerb), might be beneficial.
产品详情
Target SpeciesHuman
Product FormPurified IgG conjugated to Alexa Fluor® 488 - liquid
PreparationPurified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
ReconstitutionReconstitute with 1.0 ml distilled water
Buffer SolutionPhosphate buffered saline
Preservative Stabilisers0.09% Sodium Azide (NaN3)1% Bovine Serum Albumin
Approx. Protein ConcentrationsIgG concentration 0.05 mg/ml
ImmunogenExtracellular domain of human EGF-receptor from head and neck carcinoma.
Max Ex/EmFluorophoreExcitation Max (nm)Emission Max (nm)
Alexa Fluor®488495519
AcknowledgementsThis product is provided under an intellectual property licence from Life Technologies Corporation. The transfer of this product is contingent on the buyer using the purchase product solely in research, excluding contract research or any fee for service research, and the buyer must not sell or otherwise transfer this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; (c) manufacturing or quality assurance or quality control, or (d) resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad CA 92008 USA or outlicensing@thermofisher.com
RegulatoryFor research purposes only
Guarantee12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light.
应用
Application NameVerifiedMin DilutionMax Dilution
Flow Cytometry
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
推荐产品
DescriptionProduct CodeApplicationsPack Size
Rat IgG2a Negative Control:Alexa Fluor® 488MCA6005A488F0.1mg
文献
1.Styles, J.M.et al.(1990) Rat monoclonal antibodies to the external domain of the product of the C-erbB-2 proto-oncogene.Int J Cancer. 45 (2): 320-4.2.Dean, C.J.et al.(1993) Rat MAbs to the product of the c-erbB-2 proto-oncogene for diagnosis and therapy in breast cancer.Cell Biophys. 22 (1-3): 111-27.3.Shah, A.J.et al.(2014) Non-invasive molecular profiling of cancer using photoacoustic imaging of functionalized gold nanorodsProc. of SPIE Vol. 8943, 89435G

技术参数

产品应用 Flow

产品类型 Monoclonal Antibody

推荐用于 Flow

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