Mouse anti Mouse CD161 / NK1.1:StarBright Violet 610

货号：MCA1266SBV610

规格：100 Tests/0.5ml

价格：3885

产品类型：流式抗体

品牌：Bio-Rad

抗原：CD161 / NK1.1

物种：小鼠

宿主：小鼠

抗体亚型：IgG2a

克隆号：PK136

荧光染料：StarBright Violet 610

类型：	单抗	同型对照：	IgG2a
浓度：		用法：	5.0 µl/test(Flow)
免疫原性：	Spleen and bone marrow cells from CE mice.

Mouse anti Mouse CD161 / NK1.1 antibody, clone PK136recognizes the mouse NK1.1 cell surface antigen, a cell surface glycoprotein encoded by members of the NKR-P1 gene family. The NK1.1 surface antigen is also known as CD161b/CD161c and Ly-55.In the mouse the NKR-P1 family has three members, NKR-P1A, -B and -C, whilst in the human only one member has been identified. The human protein has received the designation CD161, and the mouse proteins have been referred to as CD161a, -b, -c etc.Although previously thought to recognize only CD161c, recent data has shown that the PK136 antibody may also react with CD161b. CD161c expression itself is strain specific in mice, but recognition of CD161b by PK136 appears to be even more complex, as only some CD161b positive strains are labelled by the antibody. Engagement of CD161c has been reported to have activating function in NK cells, whilst engagement of CD161b is inhibitory.Mouse anti Mouse NK1.1 Antigen antibody, clone PK136 is useful for the identification of NK cells in selected strains of mice (positive on C57BL, FVB/N and NZB, but negative on AKR and BALB/c) and is also expressed by rare subsets of T cells and monocytes. Mouse anti Mouse NK1.1 antibody, clone PK136 has also been used forin vivodepletion of NK cells andin vitroactivation of NK cells.

数据

Figure A. Alexa Fluor 647 conjugated Rat anti Mouse CD122 (MCA2363A647). Figure B. Alexa Fluor 647 conjugated Rat anti Mouse CD122 (MCA2363A647) and StarBright Violet 610 conjugated Mouse anti Mouse CD161 (MCA1266SBV610). All experiments performed on red blood lysed mouse blood gated on live single cell lymphocytes, in the presence of 10% mouse serum. Data acquired on theZE5 Cell Analyzer.

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参考文献：

1.Kung, S.K. & Miller RG (1995) The NK1.1 antigen in NK-mediated F1 antiparent killingin vitro.J Immunol. 154 (4): 1624-33.2W.ang, M.et al.(1998) Natural killer cell depletion fails to influence initial CD4 T cell commitment in vivo in exogenous antigen-stimulated cytokine and antibody responses.J Immunol. 160 (3): 1098-105.3.Koo, G.C.et al.(1986) The NK-1.1(-) mouse: a model to study differentiation of murine NK cells.J Immunol. 137 (12): 3742-7.4.Kung, S.K.et al.(1999) The NKR-P1B gene product is an inhibitory receptor on SJL/J NK cells.J Immunol. 162 (10): 5876-87.5.Carlyle, J.R.et al.(1999) Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function.J Immunol. 162 (10): 5917-23.6.Carnemolla, B.et al.(2002) Enhancement of the antitumor properties of interleukin-2 by its targeted delivery to the tumor blood vessel extracellular matrix.Blood. 99: 1659-65.7.Carpentier, A.F.et al.(1999) Oligodeoxynucleotides containing CpG motifs can induce rejection of a neuroblastoma in mice.Cancer Res. 59: 5429-32.8.Sakai, T.et al.(2010) Inflammatory disease and cancer with a decrease in Kupffer cell numbers in Nucling-knockout mice.Int J Cancer. 126: 1079-94.9.Svensson, L.et al.(2003) gammadelta T cells contribute to the systemic immunoglobulin E response and local B-cell reactivity in allergic eosinophilic airway inflammation.Immunology. 108 (1): 98-108.10.Hazlett, L.D.et al.(2007) NKT cells are critical to initiate an inflammatory response afterPseudomonas aeruginosaocular infection in susceptible mice.J Immunol. 179 : 1138-46.

技术参数

产品应用 Flow

产品类型 单克隆抗体

推荐用于 Flow

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