Bio-Rad MCA1270PE CD13抗体,mouse anti human CD13:RPE-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Bio-Rad MCA1270PE CD13抗体,mouse anti human CD13:RPE

2024-10-22

mouse anti human CD13:RPE

货号：MCA1270PE

规格：100 Tests

价格：4038

产品类型：流式抗体

品牌：Bio-Rad

抗原：CD13

物种：人

宿主：小鼠

抗体亚型：IgG1

克隆号：WM15

荧光染料：PE

产品介绍
Mouse anti Human CD13 antibody, clone WM15recognizes human CD13 also known as aminopeptidase N. CD13 is a single pass type II glycosylated integral membrane protein with a predicted molecular mass of ~110 kDa and an apparent molecular mass of ~150 kDa expressed by granulocytes, monocytes, fibroblasts, endothelial cells and by myeloid leukaemia cells (Bradstocket al.1985). CD13 acts as a major cell surface receptor for group 1 coronoviruses (Breslinet al.2003) which bind to a critical sequence encompassing amino acid residies 288-295 (Kolbet al.1997).CD13 functions as anaminopeptidaseenzyme, a metalloprotease present as both a membrane bound form and also a soluble aminopeptidase N.Mouse anti Human CD13, clone WM15 inhibits infection of cells by human coronavirus (Lachanceet al.1998) but not hepatitis C virus (Koutsoudakiset al.2006) and inhibits aminopeptidase N activity of the CD13 molecule (Asmunet al.1992).
产品详情
Target Species	Human
Species Cross-Reactivity	Target Species	Cross Reactivity
Rhesus Monkey	√
N.B. Antibody reactivity and working conditions may vary between species.
Product Form	Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilized
Reconstitution	Reconstitute with 1 ml distilled water
Preparation	Purified IgG prepared by affinity chromatography on Protein A
BufferSolution	Phosphate buffered saline
Preservative Stabilisers	0.09% Sodium Azide 1% Bovine Serum Albumin 5% Sucrose
Immunogen	Human AML cells.
Approx. Protein Concentrations	IgG concentration 0.05 mg/ml
Fusion Partners	Spleen cells from immunized BALB/c mice were fused with cells of the mouse NSI myeloma cell line
Max Ex/Em	Fluorophore	Excitation Max (nm)	Emission Max (nm)
RPE 488nm laser	496	578
Regulatory	For research purposes only
Guarantee	12 monthsfrom date of despatch
存储条件
Prior to reconstitution store at +4oC. Following reconstitution store at +4oC.DO NOT FREEZE.This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
应用
Application Name	Verified	Min Dilution	Max Dilution
Flow Cytometry	√	Neat	Neat
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewedpublications or personal communications fromthe originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls. Flow Cytometry Use 10ul of the suggested working dilution to label 106cells or 100ul whole blood
同型
Description	Product Code	Applications	Pack Size
Mouse IgG1 Negative Control:RPE	MCA928PE	F	100 Tests
相关产品
Description	Product Code	Applications	Pack Size
Human Seroblock	BUF070A	F	50 Test
Human Seroblock	BUF070B	F	200 Test
文献
1. Stolzing, A.et al.(2008) Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies.Mech Ageing Dev. 129: 163-73.2. Silk, K.M.et al.(2012) Rapamycin conditioning of dendritic cells differentiated from human ES cells promotes a tolerogenic phenotype.J Biomed Biotechnol. 2012:172420.3. Negussie, A.H.et al.(2010) Synthesis and in vitro evaluation of cyclic NGR peptide targeted thermally sensitive liposome.J Control Release. 143: 265-73.4. Lassnig, C.et al.(2005) Development of a transgenic mouse model susceptible to human coronavirus 229E.Proc Natl Acad Sci U S A. 102 (23): 8275-80.5. Thielitz, A.et al.(2004) Identification of extra- and intracellular alanyl aminopeptidases as new targets to modulate keratinocyte growth and differentiation.Biochem Biophys Res Commun. 321 (4): 795-801.6. McCormack, E.et al.(2013) Multiplexed mAbs: a new strategy in preclinical time-domain imaging of acute myeloid leukemia.Blood. 121 (7): e34-42.7. Fiddler, C.A.et al.(2016) The Aminopeptidase CD13 Induces Homotypic Aggregation in Neutrophils and Impairs Collagen Invasion.PLoS One. 11 (7): e0160108.8. Chaturvedi, C.P.et al.(2018) Altered Expression of Hematopoiesis Regulatory Molecules in Lipopolysaccharide-Induced Bone Marrow Mesenchymal Stem Cells of Patients with Aplastic Anemia.Stem Cells Int. 2018: 6901761.

技术参数

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Bio-Rad MCA1270PE CD13抗体,mouse anti human CD13:RPE

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