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Bio-Rad MCA1226GA CD6抗体,Mouse anti Human CD8

2024-10-22

Mouse anti Human CD8

货号：MCA1226GA,MCA1226,MCA1226T

规格：0.1 mg,0.2 mg,25 µg

价格：2023,3315,893

产品类型：流式抗体

品牌：Bio-Rad

抗原：CD8

物种：人

宿主：小鼠

抗体亚型：IgG1

克隆号：LT8

荧光染料：Purified

产品介绍
Mouse anti Human CD8 antibody, clone LT8recognizes the human CD8 cell surface glycoprotein expressed by a subset of peripheral blood T cells which express cytotoxic/suppressor activity. It is also expressed weakly on NK cells.The CD8 antigen is a co-receptor for MHC Class I in conjunction with the T cell receptor, and is important in the selection process of CD8+ MHC Class I restricted T cells.
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
Species Cross-Reactivity	Target Species	Cross Reactivity
Marmoset	√
Chimpanzee	√
Cynomolgus monkey	√
Red-bellied Tamarin	√
N.B. Antibody reactivity and working conditions may vary between species.
Preparation	Purified IgG prepared by ion exchange chromatography
BufferSolution	Phosphate buffered saline
Preservative Stabilisers	0.09% Sodium Azide (NaN3)
Immunogen	Normal human peripheral blood lymphocytes.
Approx. Protein Concentrations	IgG concentration 1.0 mg/ml
Fusion Partners	Spleen cells from immunised BALB/c mice were fused with cells of the mouse X63.653 myeloma cell line.
Regulatory	For research purposes only
Guarantee	12 monthsfrom date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
Flow Cytometry	√	1/50	1/100
Immunohistology - Frozen	√
Immunoprecipitation	√
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications fromthe originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude itsuse in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. Flow Cytometry Use 10ul of the suggested working dilution to label 10⁶cells or cells or 100ul human whole blood.
同型
Description	Product Code	Applications	Pack Size
Mouse IgG1 Negative Control	MCA928	F	100 Tests/1ml
相关产品
Description	Product Code	Applications	Pack Size
Human Seroblock	BUF070A	F	50 Test
Human Seroblock	BUF070B	F	200 Test
数据
Immunoperoxidase staining of a human tonsil cryosection with Mouse anti Human CD8 antibody, clone LT8 (MCA1226). Low power
文献
1. Nelson, M.et al.(2010) Characterization of lethal inhalational infection withFrancisella tularensisin the common marmoset (Callithrix jacchus).J Med Microbiol. 59: 1107-13.2. Gibbings, D.J.et al.(2007) CD8 alpha is expressed by human monocytes and enhances Fc gamma R-dependent responses.BMC Immunol. 8: 12.3. Junker, A.et al.(2007) Multiple sclerosis: T-cell receptor expression in distinct brain regions.Brain. 130: 2789-99.4. Held, K.et al.(2011) Expression of herpes simplex virus 1-encoded microRNAs in human trigeminal ganglia and their relation to local T-cell infiltrates.J Virol. 85 (19): 9680-5.5. Hood SPet al.(2014) Changes in immune cell populations in the periphery and liver of GBV-B-infected and convalescent tamarins (Saguinus labiatus).Virus Res. 179: 93-101.6. Nelson, M. & Loveday, M. (2014) Exploring the innate immunological response of an alternative nonhuman primate model of infectious disease; the common marmoset.J Immunol Res. 2014: 913632.7. Manivannan, K.et al.(2016) CADM1/TSLC1 Identifies HTLV-1-Infected Cells and Determines Their Susceptibility to CTL-Mediated Lysis.PLoS Pathog. 12 (4): e1005560.8. Gross, C.C.et al.(2016) Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation.Proc Natl Acad Sci U S A. 113 (21): E2973-82.9. Dunham, J.et al.(2016) Blockade of CD127 Exerts a Dichotomous Clinical Effect in Marmoset Experimental Autoimmune Encephalomyelitis.J Neuroimmune Pharmacol. 11 (1): 73-83.10. Bughani, U.et al.(2017) T cell activation and differentiation is modulated by a CD6 domain 1 antibody Itolizumab.PLoS One. 12 (7): e0180088.11. Philippens, I.H.et al.(2017) Acceleration of Amyloidosis byInflammation in the Amyloid-Beta Marmoset Monkey Model of Alzheimer's Disease.J Alzheimers Dis. 55 (1): 101-113.

技术参数

产品应用 IHC;Flow;IP

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Bio-Rad MCA1226GA CD6抗体,Mouse anti Human CD8

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