CD11c Monoclonal Antibody (3.9), PE, eBioscience™

货号：12-0116-42,12-0116-41

规格：100 tests,25 tests

价格：2431,934

产品类型：流式抗体

品牌：eBioscience

抗原：CD11c

物种：人/恒河猴

宿主：小鼠

抗体亚型：IgG1, kappa

克隆号： 3.9

荧光染料：PE

类型:	一抗	同型对照：	Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE, eBioscience™
浓度：	5 µL/Test	用法：	5 µL (1 µg)/test（Flow）

产品详细信息Description: The 3.9 monoclonal antibody reacts with human CD11c, the 150 kDa integrin alphaX chain. CD11c non-covalently associates with beta2 integrin to form the CD11c/CD18 heterodimer. This complex is expressed on monocytes, granulocytes, macrophages, NK, dendritic cells and subset of T and B lymphocytes. CD11c/CD18 binds to CD54, iC3b and fibrinogen and plays a role in leukocyte adhesive interactions.Applications Reported: The 3.9 antibody has been reported for use in flow cytometric analysis.Applications Tested: The 3.9 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (1 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息CD11, along with CD18, form a heterodimer adhesion molecule. In particular, CD11 is composed of CD11a, CD11b and CD11c. CD11a is a leukocyte marker that is expressed in B and T lymphocytes, macrophages, monocytes, neutrophils, basophils and eosinophils. CD11b is primarily expressed by monocytes, macrophages, natural killer cells, some B and T-cells, and granulocytes. CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes.仅用于科研。不用于诊断过程。

数据

CD11c Antibody (12-0116-42) in FlowStaining of normal human peripheral blood cells with Mouse IgG1 kappa Isotype Control PE (Product # 12-4714-81) (blue histogram) or Anti-Human CD11c PE (purple histogram). Cells in the monocyte gate were used for analysis.

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参考文献：

1. PloS onePenicillium marneffei-stimulated dendritic cells enhance HIV-1 trans-infection and promote viral infection by activating primary CD4+ T cells."12-0116 was used in Flow cytometry/Cell sorting to demonstrate that DC interaction with HIV-1 has been exploited by P. marneffei for viral amplification."AuthorsQin Y,Li Y,Liu W,Tian R,Guo Q,Li S,Li H,Zhang D,Zheng Y,Wu L,Lan K,Wang JYear2012SpeciesHuman 2. RetrovirologyDendritic cell subsets dynamics and cytokine production in SIVmac239-infected Chinese rhesus macaques."12-0116 was used in Flow cytometry/Cell sorting to investigate the dynamic and functional changes in dendritic cell subsets in SIVmac239-infected Chinese rhesus macaques."AuthorsXia HJ,Zhang GH,Ma JP,Dai ZX,Li SY,Han JB,Zheng YTYear2010SpeciesRhesus monkey 3. The Journal of clinical investigationAn adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice."12-0116 was used in Flow cytometry/Cell sorting to identify a vascular inflammatory pathway that contributes to the development of cardiovascular disease."AuthorsTieu BC,Lee C,Sun H,Lejeune W,Recinos A,Ju X,Spratt H,Guo DC,Milewicz D,Tilton RG,Brasier ARYear2009SpeciesHuman 4. Cellular & molecular immunologyThe influence of age and sex on the cell counts of peripheral blood leukocyte subpopulations in Chinese rhesus macaques."12-0116 was used in Flow cytometry/Cell sorting to provide basic information about the leukocyte subpopulations of Chinese rhesus macaques."AuthorsXia HJ,Zhang GH,Wang RR,Zheng YTYear2009SpeciesRhesus monkey 5. Journal of virologyInduction of robust immune responses against human immunodeficiency virus is supported by the inherent tropism of adeno-associated virus type 5 for dendritic cells."12-0116 was used in Flow cytometry/Cell sorting to investigate the ability of different adeno-associated virus vectors expressing the human immunodeficiency virus to induce a robust immune response, and the factors which affect this."AuthorsXin KQ,Mizukami H,Urabe M,Toda Y,Shinoda K,Yoshida A,Oomura K,Kojima Y,Ichino M,Klinman D,Ozawa K,Okuda K

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