CD42d Monoclonal Antibody (1C2), APC, eBioscience™

货号：17-0421-82,17-0421-80

规格：100 µg,25 µg

价格：3202,1442

产品类型：流式抗体

品牌：eBioscience

抗原：CD42d

物种：小鼠

宿主：Armenian hamster仓鼠

抗体亚型：IgG

克隆号： 1C2

荧光染料：APC

类型:	一抗	同型对照：	Armenian Hamster IgG Isotype Control (eBio299Arm), APC, eBioscience™
浓度：	0.2 mg/mL	用法：	0.5 µg/test（Flow）

产品详细信息Description: The monoclonal antibody 1C2 recognizes mouse and rat CD42d, a single transmembrane protein also known as platelet glycoprotein V (GPV). CD42d interacts with CD42a, CD42b and CD42c to form the receptor for von willebrand factor and thrombin. This functional complex plays a role in platelet adhesion. Expression of CD42d (unlike other markers such as CD41) is restricted to resting platelets and megakaryocytes and therefore is a good marker for development ofmegakaryocytes.Applications Reported: This 1C2 antibody has been reported for use in flow cytometric analysis.Applications Tested: This 1C2 antibody has been tested by flow cytometric analysis of mouse platelets. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息Natural killer (NK) cells in teleosts and their evolutionary homologue are a subpopulation of lymphocytes with properties that distinguish them from either B- or T-cells. NK cells are important effectors of innate immunity where they release cytokines, which in turn up-regulate other immunological functions. Monoclonal antibodies have been used to identify different surface antigens present on NK cells. These surface antigens have not only been used to identify NK cells, but also their functionally distinct subsets. The Cluster of Differentiation (CD) nomenclature was established to standardize the naming of NK cells.仅用于科研。不用于诊断过程。

数据

CD42d Antibody (17-0421-82) in FlowStaining of mouse platelets with Anti-Mouse CD41 FITC (Product # 11-0411-82) and 0.25 µg of Armenian Hamster IgG Isotype Control APC (Product # 17-4888-82) (left) or 0.25 µg of Anti-Mouse/Rat CD42d APC (right). Total events were used for analysis.

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参考文献：

1. Blood cancer journalNovel function of FAXDC2 in megakaryopoiesis."Published figure using CD42d monoclonal antibody (Product # 17-0421-82) in Flow Cytometry"2. Nature communicationsReprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors."17-0421 was used in Flow cytometry/Cell sorting to demonstrate how it is possible to reprogram mouse embryonic fibroblasts into engraftable blood progenitors."AuthorsCheng H,Ang HY,A El Farran C,Li P,Fang HT,Liu TM,Kong SL,Chin ML,Ling WY,Lim EK,Li H,Huber T,Loh KM,Loh YH,Lim B3. Cell death & diseasePSTPIP2 dysregulation contributes to aberrant terminal differentiation in GATA-1-deficient megakaryocytes by activating LYN."Published figure using CD42d monoclonal antibody (Product # 17-0421-82) in Flow Cytometry"

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