Human Anti-Nivolumab Antibody, clone AbD30255 HCA299 bio-rad ,Human Anti-Nivolumab Antibody, clone AbD30255-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Human Anti-Nivolumab Antibody, clone AbD30255 HCA299 bio-rad ,Human Anti-Nivolumab Antibody, clone AbD30255

2024-10-22

Human Anti-Nivolumab Antibody, clone AbD30255

货号：HCA299

规格：0.1 mg

价格：3851

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：Nivolumab

物种：其它

宿主：人

抗体亚型：HuCAL Fab monovalent

克隆号：AbD30255

荧光染料：其它

产品介绍
Human Anti-Nivolumab Antibody, clone AbD30255is a paratope specific, inhibitory anti-idiotypic antibody that specifically recognizes the monoclonal antibody drug nivolumab. The antibody does not recognize recombinant human programmed cell death 1 (PD-1) or nivolumab in complex with recombinant human PD-1 and can be used to measure free nivolumab levels in serum from patients.A pair of anti-nivolumab antibodies can be used to develop a pharmacokinetic (PK) bridging assay to measure free drug. This antibody, in monovalent Fab format, is recommended as the capture antibody, paired with an HRP conjugated Anti-Nivolumab Antibody in full immunoglobulin format, clone AbD30258_hIgG1 (HCA301) as the detection antibody.Nivolumab (Opdivo) is a fully human antibody (IgG4/kappa), with the heavy chain mutation S228P (IgG4-Pro). It is used as a first line treatment for inoperable or metastatic melanoma in combination with ipilimumab if the cancer does not have a mutation in BRAF. It is also approved for treatment of advanced non-small cell lung cancer, advanced renal cell carcinoma, classical Hodgkin's lymphoma and advanced head and neck squamous cell carcinoma. Nivolumab is a checkpoint inhibitor and acts as an immuno-modulator by blocking ligand activation of PD-1 receptor on T cells, thereby activating T cells to attack the cancer. Nivolumab blocks PD-1 interaction with PD-1 ligand (PD-L1) and PD-1 ligand 2 (PD-L2).
产品详情
Product Form	A monovalent human recombinant Fab (lambda light chain) selected from the HuCAL® phage display library, expressed inE. coli.The antibody is tagged with a DYKDDDDK tag and a HIS-tag (HHHHHH) at the C-terminus of the antibody heavy chain. This antibody is supplied as a liquid.
Preparation	Metal chelate affinity chromatography
Buffer Solution	Phosphate buffered saline
Preservative Stabilisers	0.01% Thiomersal
Affinity	The monovalent intrinsic affinity of AbD30255 was measured as KD= 0.5 nM by real time, label free molecular interaction analysis on immobilized nivolumab
Immunogen	Nivolumab
Approx. Protein ConcePurityntrations	Antibody concentration 0.5 mg/ml
Acknowledgements	This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details.Opdivo is a trademark of Bristol-Myers Squibb Company.His-tag is a registered trademark of EMD Biosciences.
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
ELISA	√
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
产品推荐
Description	Product Code	Applications	Pack Size
Rat anti DYKDDDDK Tag	MCA4764	E	0.2mg

技术参数

产品类型 elisa

推荐用于单克隆抗体

组成成分 elisa

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Human Anti-Nivolumab Antibody, clone AbD30255 HCA299 bio-rad ,Human Anti-Nivolumab Antibody, clone AbD30255

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