Human Anti-Golimumab Antibody, clone AbD25418_hIgG1 HCA287,Human Anti-Golimumab Antibody, clone AbD25418_hIgG1-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Human Anti-Golimumab Antibody, clone AbD25418_hIgG1 HCA287,Human Anti-Golimumab Antibody, clone AbD25418_hIgG1

2024-10-22

Human Anti-Golimumab Antibody, clone AbD25418_hIgG1

货号：HCA287

规格：0.1 mg

价格：5032

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：Golimumab

物种：其它

宿主：人

抗体亚型：IgG1

克隆号：AbD25418_hIgG1

荧光染料：Purified

产品介绍
Human Anti-Golimumab Antibody, clone AbD25418_hIgG1is a paratope specific, inhibitory anti-idiotypic antibody that specifically recognizes the free human monoclonal antibody golimumab and inhibits binding to its target TNFα.Clone AbD25418_hIgG1 does not recognize free human TNFα or golimumab in complex with human TNFα. This antibody can be used to measure free golimumab and biosimilar products in bioanalytical assays.Clone AbD25418_hIgG1 is an affinity-matured variant of AbD20692 (HCA241), with about a 21-fold affinity improvement.A pair of anti golimumab antibodies can be used to develop a pharmacokinetic (PK) bridging assay to measure free drug. This antibody, in full immunoglobulin format, is recommended as the detection antibody paired with clone AbD25429 (HCA286) in monovalent Fab format as the capture antibody.Golimumab, marketed under the brand name Simponi is a recombinant human IgG1/kappa monoclonal antibody approved for the treatment of rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. This therapeutic antibody, directed against TNFα, acts by blocking the binding of TNFα to its receptors, resulting in a down-regulation of the inflammatory response associated with autoimmune diseases.
产品详情
Product Form	Human IgG1 antibody (kappa light chain) selected from the HuCAL® phage display library and expressed in a human cell line. This antibody is supplied as a liquid
Preparation	Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution	Phosphate buffered saline
Preservative Stabilisers	0.01% Thiomersal
Immunogen	Recombinant human IgG1 kappa
Approx. Protein ConcePurityntrations	IgG concentration 0.5 mg/ml
Affinity	This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details.Simponi is a registered trademark of Janssen Biotech, Inc. in the USA and Merck & Co, Inc. in Europe.
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
ELISA	√	1/100	1/1000
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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技术参数

产品应用 elisa

产品类型单克隆抗体

推荐用于 elisa

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Human Anti-Golimumab Antibody, clone AbD25418_hIgG1 HCA287,Human Anti-Golimumab Antibody, clone AbD25418_hIgG1

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