Human anti etanercept, clone AbD25940_hIgG4_Pro HCA277P bio-rad,Human anti etanercept, clone AbD25940_hIgG4_Pro-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Human anti etanercept, clone AbD25940_hIgG4_Pro HCA277P bio-rad,Human anti etanercept, clone AbD25940_hIgG4_Pro

2024-10-22

Human anti etanercept, clone AbD25940_hIgG4_Pro

货号：HCA277P

规格：0.1 mg

价格：5032

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：etanercept

物种：其它

宿主：人

抗体亚型：lgG4

克隆号：AbD25940_hIgG4_Pro

荧光染料：HRP

产品介绍
Human anti etanercept, clone AbD25940_hIgG4_Prois an antibody that specifically recognizes etanercept as well as the extracellular ligand-binding portion of the 75 kDa (p75) human tumor necrosis factor receptor 2 (TNFR2). Clone AbD25940_hIgG4_Pro inhibits the binding of etanercept to its target tumour necrosis factor alpha (TNFα). The antibody binds to free etanercept but not to etanercept bound to its target TNFα. The antibody binds to an epitope which is also part of the TNFα binding site and can be used to measure the levels of etanercept and biosimilar products (e.g. Etacept, Intacept) in bioanalytical assays.CloneAbD25940_hIgG4_Pro is a fully human recombinant monoclonal antibody with an IgG4 isotype and is suitable as a reference standard in an anti-drug antibody (ADA) assay. Additionally the antibody can be used to develop a pharmacokinetic (PK) bridging assay to measure free drug. This antibody, in full immunoglobulin format, is recommended as the detection antibody, paired with the antibody clone AbD25939 (HCA276) in monovalent Fab format, as the capture antibody.Etanercept (Enbrel®) is a dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kDa (p75) TNFR2 linked to the Fc portion of human IgG1. The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of IgG1. It is used to treat autoimmune diseases by interfering with TNF, acting as a TNF inhibitor. It binds to both TNFα and TNFβ (Lymphotoxin A).
产品详情
Product Form	Human IgG4 antibody (kappa light chain) selected from the HuCAL® phage display library and expressed in a human cell line. Conjugated to horseradish peroxidase (HRP) - liquid
Preparation	Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution	Phosphate buffered saline
Preservative Stabilisers	0.01% Thiomersal
Affinity	The monovalent intrinsic affinity of this antibody was measured as KD=2.4 nM by real time, label-free molecular interaction analysis on immobilized etanercept
Immunogen	Etanercept
Approx. Protein ConcePurityntrations	Antibody concentration 0.5 mg/ml
Acknowledgements	This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details.Enbrel is a registered trademark of Immunex Corporation.
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped frozen.When ready to use, thaw and aliquot the sample as needed. Store aliquots at -70°C, if available, otherwise store at -20°C. It is not recommended to keep aliquots at 4°C for more than one week.
应用
Application Name	Verified	Min Dilution	Max Dilution
ELISA	√
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
产品推荐
Description	Product Code	Applications	Pack Size
Hispec Assay Diluent	BUF049A	E	50 ml
Human anti Etanercept	HCA279	E	0.1mg

技术参数

产品应用 elisa

产品类型单克隆抗体

推荐用于 elisa

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Human anti etanercept, clone AbD25940_hIgG4_Pro HCA277P bio-rad,Human anti etanercept, clone AbD25940_hIgG4_Pro

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