Human anti Alemtuzumab antibody, clone AbD19189 HCA198 , Human anti Alemtuzumab antibody, clone AbD19189-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Human anti Alemtuzumab antibody, clone AbD19189 HCA198 , Human anti Alemtuzumab antibody, clone AbD19189

2024-10-22

Human anti Alemtuzumab antibody, clone AbD19189

货号：HCA198

规格：0.1 mg

价格：4522

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：Alemtuzumab

物种：其它

宿主：人

抗体亚型：HuCAL Fab monovalent

克隆号：AbD19189

荧光染料：Purified

产品介绍
Human anti Alemtuzumab antibody, clone AbD19189recognizes alemtuzumab, a monoclonal antibody drug directed to human CD52 and used in the treatment of chronic lymphocytic leukemia (CLL), cutaneous T-cell lymphoma (CTCL) and T-cell lymphoma. Alemtuzumab is also used in some conditioning regimes for bone marrow transplantation, kidney transplantation and Islet cell transplantation along with clinical trial protocols for treatment of certain autoimmune diseases including multiple sclerosis.Human anti Alemtuzumab antibody, clone AbD19189 is an anti-idiotypic antibody that specifically recognizes the alemtuzumab humanized monoclonal antibody and and can be used to measure the levels of alemtuzumab and biosimilar products using bioanalytical assays.This antibody may be used in a bridging ELISA in conjunction with horseradish peroxidase conjugated cloneAbD19189_hIgG1or cloneAbD16942.Clone AbD19189 has been demonstrated to inhibit the binding of alemtuzumab to CD52-positive human cells in flow cytometry. It also blocks the binding of Rat anti Human CD52 antibody,clone YTH34.5, the Rat monoclonal prototype antibody of alemtuzumab, to CD52+ cells.
产品详情
Product Form	A monovalent human recombinant Fab (lambda light chain) selected from the HuCAL® phage display library, expressed inE. coli.The antibody is tagged with a DYKDDDDK tag and a HIS-tag (HHHHHH) at the C-terminus of the antibody heavy chain. This antibody is supplied as a liquid.
Preparation	Metal chelate affinity chromatography.
Buffer Solution	Phosphate buffered saline
Preservative Stabilisers	0.01% Thiomersal
Immunogen	Alemtuzumab.
Affinity	The monovalent intrinsic affinity of this antibody was measured as KD=0.2 nM by real time, label-free molecular interaction analysis on immobilized alemtuzumab.
Approx. Protein ConcePurityntrations	Total protein concentration 0.5 mg/ml.
Acknowledgements	This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details.His-tag is a registered trademark of EMD Biosciences.
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
ELISA	√
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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技术参数

产品应用 elisa

产品类型单克隆抗体

推荐用于 elisa

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Human anti Alemtuzumab antibody, clone AbD19189 HCA198 , Human anti Alemtuzumab antibody, clone AbD19189

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