Rabbit anti Rat connexin 43 (pSer368) antibody AHP977 bio-rad,Rabbit anti Rat connexin 43 (pSer368) antibody-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Rabbit anti Rat connexin 43 (pSer368) antibody AHP977 bio-rad,Rabbit anti Rat connexin 43 (pSer368) antibody

2024-10-22

Rabbit anti Rat connexin 43 (pSer368) antibody

货号：AHP977

规格：0.1 ml

价格：6095

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：connexin 43 (pSer368)

物种：大鼠

宿主：兔

抗体亚型：IgG

荧光染料：Purified

产品介绍
Rabbit anti Rat connexin 43 (pSer368) antibodyrecognizes connexin 43 (Cx43), also known as gap junction alpha-1 protein and gap junction 43 kDa heart protein, when phosphorylated at serine 368.Connexin 43 allows for the exchange of solutions between neighbouring cells through the formation of gap-junctional channels and is expressed in the brain, kidneys and myocardium, as well as vascular endothelial cells. A decrease in the permeability of gap-junctional channels occurs due to a conformational change in the structure of connexin 43, and that this is mediated by the phosphorylation of connexin 43 at residue serine 368, by Protein Kinase C (Baoet al.2004).A possible link between connexin 43 and epilepsy has been investigated following the detection of high levels of connexin 43 in both low-grade tumours and peritumoural reactive astrocytes (Aronicaet al.2001).
产品详情
Target Species	Rat
Species Cross-Reactivity	Target Species	Cross Reactivity
Zebrafish	√
Chicken	√
Guinea Pig	√
N.B. Antibody reactivity and working conditions may vary between species.
Product Form	Purified IgG - liquid
Antiserum Preparation	Antisera to rat connexin43 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Buffer Solution	10mM HEPES pH7.5
Immunogen	Synthetic phosphopeptide corresponding to an amino acid sequence within connexin43 which includes phosphorylated Ser368
Approx. Protein Concentrations	IgG concentration 1.0 mg/ml
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
Western Blotting	√		1/1000
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
二抗
Description	Product Code	Applications	Pack Size
Goat anti Rabbit IgG (Fc):Biotin	STAR121B	E,WB	1mg
Goat anti Rabbit IgG (H/L):HRP	STAR124P	C,E,WB	1mg
文献
1.Bao, X.et al.(2004) Mechanism of regulation of the gap junction protein connexin 43 by protein kinase C-mediated phosphorylation.Am J Physiol Cell Physiol. 286 (3): C647-54.2.Bao, X.et al.(2004) Regulation of purified and reconstituted connexin 43 hemichannels by protein kinase C-mediated phosphorylation of Serine 368.J Biol Chem. 279 (19): 20058-66.3.Aronica, E.et al.(2001) Expression of connexin 43 and connexin 32 gap-junction proteins in epilepsy-associated brain tumors and in the perilesional epileptic cortex.Acta Neuropathol. 101 (5): 449-59.

技术参数

产品应用 wb

产品类型多克隆抗体

推荐用于 wb

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Rabbit anti Rat connexin 43 (pSer368) antibody AHP977 bio-rad,Rabbit anti Rat connexin 43 (pSer368) antibody

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