Bio-Rad AHP2039 HUWE1,Rabbit anti Human HUWE1 antibody-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Bio-Rad AHP2039 HUWE1,Rabbit anti Human HUWE1 antibody

2024-10-22

Rabbit anti Human HUWE1 antibody

货号：AHP2039

规格：50 µg

价格：5882

产品类型：抗体和ELISA

品牌：Bio-Rad

产品介绍
Rabbit anti Human HUWE1 antibodyrecognizes human E3 ubiquitin-protein ligase HUWE1, also known as HUWE1, ARF-binding protein 1, ARF-BP1, HECT, UBA and WWE domain-containing protein 1, Homologous to E6AP carboxyl terminus homologous protein 9, HectH9, Large structure of UREB1, LASU1, Mcl-1 ubiquitin ligase E3, Mule or Upstream regulatory element-binding protein 1. HUWE1 is a 4374 amino acid DNA binding protein with a predicted molecular mass of ~480 kDa.HUWE1 is an E3 ubiquitin-protein ligase involved in mediating ubiquitination and subsequent proteasomal degradation of target proteins. HUWE1 is also involved in apoptosis through catalyzation of the poly-ubiquitination and degradation of MCL1, ubiquitination of the p53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Research indicates that HUWE1 regulates the abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (Hallet al.2007).
产品详情
Target Species	Human
Species Cross-Reactivity	Target Species	Cross Reactivity
Mouse	√
Rat	√
N.B. Antibody reactivity and working conditions may vary between species.
Product Form	Purified IgG - liquid
Antiserum Preparation	Antiserum to human HUWE1 was raised by repeated immunisation of rabbits with highly purified antigen.Purified IgG prepared from whole serum by affinity chromatography.
Buffer Solution	Phosphate buffered saline
Preservative Stabilisers	<0.1% Sodium Azide (NaN3)
Immunogen	A synthetic peptide corresponding to an 19 amino acid sequence from near the carboxy terminal of human HUWE1.
Approx. Protein Concentrations	Total protein concentration 1.0mg/ml
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
Prior to reconstitution store at -20°C.After reconstitution store at -20°C.This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
应用
Application Name	Verified	Min Dilution	Max Dilution
Immunohistology - Paraffin¹	√	5.0ug/ml
Western Blotting	√	2.0ug/ml
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.ImmunohistologyThis product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.Histology Positive Control TissueHuman brain (cortex) or human heart
数据
Staining of formalin fixed, paraffin embedded human brain cortex with Rabbit anti Human HUWE1 (AHP2039).
相关试剂
Description	Product Code	Applications	Pack Size
Antigen Retrieval Buffer, pH8.0	BUF025A	IHC(P)	500 mL
TidyBlot Western Blot Detection Reagent:HRP	STAR209P	WB	0.5 mL

技术参数

产品应用 P;WB

产品类型 Polyclonal Antibody

推荐用于 P;WB

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Bio-Rad AHP2039 HUWE1,Rabbit anti Human HUWE1 antibody

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