产品介绍

Rabbit anti Human BDNF antibodyrecognizes human brain-derived neurotrophic factor (BDNF), also known as abrineurin. BDNF is a secreted 119 amino acid ~30 kDa protein with an additional 18 amino acid signal peptide and a 110 amino acid propeptide region. BDNF is a potent neurotrophin and member of the NGF-beta family, secreted from dense core vesicles, which promotes the growth, differentiation and survival of neurons within, or directly connected to, the central nervous system (CNS).BDNF signals through binding to the high affinity receptor trkB, and also binds to the low affinity neurotrophin receptor LNGFR. BDNF is involved in the modulation of short-term synaptic function and in the formation of long-term memory (Alonsoet al.2002). BDNF is modulated during progression of Alzheimer's with an early increase and reducel levels in patients with latter stages of Alzheimer's (Laskeet al.2005). Decreased levels of BDNF are also noted in the progression of Huntington's disease (Zuccatoet al.2008) .

产品详情

Target Species

Product Form

Antiserum Preparation

Buffer Solution

Preservative Stabilisers

Approx. Protein Concentrations

Immunogen

Regulatory

Guarantee

Reconstitution

存储条件

Prior to reconstitution store at -20°C.After reconstitution store at -20°C.This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

应用

Application Name

Verified

Min Dilution

Max Dilution

ELISA

√

0.5

2.0ug/ml

Western Blotting

√

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.

Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

• ELISA

• This purified human BDNF antibody may be used in an indirect ELISA or as the capture reagent in a sandwich ELISA with ourbiotinylated human BDNF antibody(AHP1831B) as the detection reagent andrecombinant human BDNF(PHP213) as the standard.

相关产品

Description

Product Code

Applications

Pack Size

Goat anti Rabbit IgG (Fc):Biotin

STAR121B

E;WB

1 mg

Goat anti Rabbit IgG (Fc):FITC

STAR121F

Flow

1 mg

Goat anti Rabbit IgG (Fc):HRP

STAR121P

E;WB

1 mg

Goat anti Rabbit IgG (H/L):HRP

STAR124P

C;E;WB

1 mg

Sheep anti Rabbit IgG:FITC

STAR34B

C;F

1 mg