Bio-Rad AHP1537 alpha synuclein (pSer129),Rabbit anti Rat alpha synuclein (pSer129) antibody-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Bio-Rad AHP1537 alpha synuclein (pSer129),Rabbit anti Rat alpha synuclein (pSer129) antibody

2024-10-22

Rabbit anti Rat alpha synuclein (pSer129) antibody

货号：AHP1537

规格：0.1 ml

价格：6095

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：alpha synuclein (pSer129)

物种：大鼠

宿主：兔

抗体亚型：IgG

荧光染料：Purified

产品介绍
Rabbit anti Rat alpha synuclein (pSer129) antibodyrecognizes alpha synuclein when phosphorylated at serine 129. Alpha synuclein is a 140 amino acid, ~15 kDa protein seen predominantly in the neocortex, hippocampus, substantia nigra, thalamus and cerebellum. Its normal cellular function has not been definitively determined, but it is thought to be involved in the regulation of neuronal plasticity, dopamine neurotransmission and other membrane-associated processes at the presynaptic terminal.Alpha synuclein is normally a soluble, unfolded protein, but it can aggregate at high concentrations to form insoluble fibrils which, in association with other proteins such as ubiquitin, neurofilament protein and alpha B crystalline, form Lewy bodies. Lewy bodies are a hallmark pathological feature of Parkinson's disease and other neurodegenerative diseases. Alpha synuclein has several possible phosphorylation sites, serine 129 in particular can be phosphorylated by G-protein-coupled receptor kinases and this phosphorylation promotes formation of alpha synuclein filaments, with hyperphosphorylation of serine129 seen in Lewy bodies.
产品详情
Target Species	Rat
Product Form	Purified IgG - liquid
Antiserum Preparation	Antisera to Alpha Synulein (pSer129) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Buffer Solution	10mM Hepes pH7.5, 150mM NaCl
Preservative Stabilisers	0.09%Sodium Azide (NaN3)50%Glycerol0.01%Bovine Serum Albumin
Immunogen	Synthetic phosphopeptide corresponding to amino acid sequence surrounding phosphorylated serine 129 of Alpha Synuclein.
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
Western Blotting	√		1/1000
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls. Western Blotting AHP1537 detects a band of approximately 15kDa in rat cortex lysate.
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数据
Western blot of rat cortex lysate showing phospho-specific labeling of the ~15 kDa alpha synuclein protein phosphorylated at Ser129using Rabbit anti Mouse alpha synuclein (pSer129) antibody (AHP1537).
文献
1. Smith, W. W.et al(2005) Alpha-Synuclein Phosphorylation Enhances Eosinophilic Cytoplasmic Inclusion Formation in SH-SY5Y Cells.J. Neurosci. 25: 5544-52.

技术参数

产品应用 WB

产品类型 Polyclonal Antibody

推荐用于 WB

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Bio-Rad AHP1537 alpha synuclein (pSer129),Rabbit anti Rat alpha synuclein (pSer129) antibody

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