Rabbit anti ASK1 (pSer83) antibody AHP1242 BIO-rad,Rabbit anti ASK1 (pSer83) antibody

2024-10-22

Rabbit anti ASK1 (pSer83) antibody

货号:AHP1242

规格:50 µg

价格:1870

产品类型:免疫组化一抗

品牌:Bio-Rad

抗原:ASK1 (pSer83)

物种:其它

宿主:兔

抗体亚型:IgG

荧光染料:Purified

产品介绍
Rabbit anti ASK1 (pSer83) antibodyrecognizes apoptosis signal-regulating kinase 1 (ASK1), also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5) and MAPK/ERK kinase kinase 5 (MEKK 5), when phosphorylated at serine 83. ASK1 is a serine/threonine kinase that plays an important role in the apoptotic response to various stimuli including oxidative stress, cytokines (e.g. TNF) and endoplasmic reticulum stress. Akt in conjunction to Hsp90 phosphorylates ASK1 at serine 83 to inhibit ASK1 induced apoptosis.
产品详情
Target SpeciesHuman
Product FormPurified IgG - liquid
Antiserum PreparationAntisera to ASK1 (pSER83) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by ion exchange chromatography.
Buffer SolutionPhosphate buffered saline
ImmunogenKLH conjugated peptide corresponding to amino acids 76-87 of human ASK-1 protein.
Approx. Protein ConcentrationsIgG concentration 2.0mg/ml
RegulatoryFor research purposes only
Guarantee12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application NameVerifiedMin DilutionMax Dilution
ELISA1/5,0001/10,000
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
二抗
DescriptionProduct CodeApplicationsPack Size
Goat anti Rabbit IgG (Fc):BiotinSTAR121BE,WB1mg
Goat anti Rabbit IgG (H/L):HRPSTAR124PC,E,WB1mg
文献
1.Zhang, R.et al. (2005) Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis.Oncogene. 24: 3954-3963.2.Hayakawa, T.et al. (2006) The ASK1-MAP kinase pathways in immune and stress responses.Microbes Infect. 8: 1098-1107.3.Takeda, K.et al. (2003) Roles of MAPKKK ASK1 in stress-induced cell death.Cell Struct. Funct. 28: 23-29.

技术参数

产品应用 elisa;wb

产品类型 Polyclonal Antibody

推荐用于 elisa;wb

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