eBioscience 小鼠B细胞CD40单克隆抗体 APC,CD40 Monoclonal Antibody (1C10), APC, eBioscience-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

eBioscience 小鼠B细胞CD40单克隆抗体 APC,CD40 Monoclonal Antibody (1C10), APC, eBioscience

2024-10-24

CD40 Monoclonal Antibody (1C10), APC, eBioscience

货号：17-0401-81,17-0401-82

规格：50μg,100μg

价格：1897,3163

产品类型：流式抗体

品牌：eBioscience

抗原：CD40

物种：小鼠

宿主：大鼠

抗体亚型：IgG2a, kappa

克隆号：1C10

荧光染料：APC

抗体类型	流式抗体	同型对照：	Rat IgG2a kappa Isotype Control (eBR2a), APC, eBioscience™
浓度：	0.2 mg/mL	用法：	0.25 µg/test (Flow)
产品详细信息Description: The 1C10 monoclonal antibody reacts with mouse CD40, a 45-50 kDa type I transmembrane glycoprotein. CD40 is a member of the TNFR family and is expressed by mouse B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells. CD40 regulates B cell development/maturation by inducing Ig isotype switching and in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with CD154 (gp39), its ligand on T cells, is important in T-B cell crosstalk and plays a role in costimulation and immune regulation.The monoclonal antibody 1C10 is reported to have agonistic activity in vitro and in vivo.Applications Reported: The 1C10 antibody has been reported for use in flow cytometric analysis.Applications Tested: The 1C10 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息The CD40 antigen is a single chain glycoprotein that is known to be a member of the tumor necrosis factor/nerve growth factor superfamily and shows a significant homology to the Hodgkin's disease associated antigen, CD30. CD40 is present on all B cells except plasma cells and is also found on some epithelial cells, carcinomas and lymphoid dendritic cells. CD40 has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of CD40, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 and serves as a mediator of the signal transduction. The interaction of CD40 and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of CD40 encoding distinct isoforms have been reported. Diseases associated with CD40 dysfunction include Type 3 Hyper-Igm immunodeficiency and CD40 ligand deficiency.
数据
CD40 Antibody (17-0401-82) in FlowStaining of BALB/c splenocytes with Anti-Mouse CD19 FITC (Product # 11-0193-82) and 0.125 µg of Rat IgG2a K Isotype Control APC (Product # 17-4321-81) (left) or 0.125 µg of Anti-Mouse CD40 APC (right). Total viable cells were used for analysis.
推荐产品：
二抗荧光二抗免疫组化一抗标签抗体
参考文献：
1.Frontiers in immunologyFcεRI γ-Chain Negatively Modulates Dectin-1 Responses in Dendritic Cells."17-0401 was used in Flow cytometry/Cell sorting to further explore the role of the tyrosine-based activation motif-containing adaptors DAP12 and FcεRI γ-chain in C-type lectin receptor responses."2.Nature communicationsChemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer."17-0401 was used in Flow cytometry/Cell sorting to show that chemo-photothermal therapy tuned to elicit anti-tumour immunity can exert striking therapeutic effects against primary and disseminated tumours."AuthorsNam J,Son S,Ochyl LJ,Kuai R,Schwendeman A,Moon JJ3.Proceedings of the National Academy of Sciences of the United States of AmericaBryostatin-1 alleviates experimental multiple sclerosis.4.Nature communicationsChemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer."17-0401 was used in Flow cytometry/Cell sorting to show that chemo-photothermal therapy tuned to elicit anti-tumour immunity can exert striking therapeutic effects against primary and disseminated tumours."AuthorsNam J,Son S,Ochyl LJ,Kuai R,Schwendeman A,Moon JJ5.JCI insightCombination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer."Published figure using CD40 monoclonal antibody (Product # 17-0401-82) in Flow Cytometry"

技术参数

© bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪是专业的授权总代理区域代理经销平台。
© 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
© 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
© 本文地址：https://gibcohyclone.cn/thread-47777.htm

特别声明：以上内容(如有图片亦包括在内)来源于授权厂家或网络，如有侵权，请联系删除，本平台不提供信息存储服务。

Notice: The content above (including the pictures if any)comes from authorized manufacturers or networks. In case of infringement, please contact to delete it. This platform does not provide information storage services.

产品询价需求提交

eBioscience 小鼠B细胞CD40单克隆抗体 APC,CD40 Monoclonal Antibody (1C10), APC, eBioscience

相关推荐