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Bio-Rad AHP1329 Mdm2,Rabbit anti Mouse Mdm2 antibody

2024-10-22

Rabbit anti Mouse Mdm2 antibody

货号：AHP1329

规格：50 µg

价格：3341

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：Mdm2

物种：小鼠

宿主：兔

抗体亚型：IgG

荧光染料：Purified

产品介绍
Rabbit anti Mouse Mdm2 antibodydetects murine Mdm2, a nuclear phosphoprotein that controls intracellular levels of the tumour suppressor protein p53 by ubiquitination and subsequent proteasomal degradation. Mdm2 also interacts with the retinoblastoma (RB) protein and E2F-1, to promote G1-S phase transition in the cell cycle.Mdm2 activity is controlled by self-ubiquitination; however activation of the PI3K/PKB pathway leads to phosphorylation of Mdm2 at Ser185, which stabilises the protein.
产品详情
Target Species	Mouse
Product Form	Purified IgG - liquid
Antiserum Preparation	Antisera to Mdm2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Buffer Solution	Phosphate buffered saline
Preservative Stabilisers	<0.1% Sodium Azide (NaN3)
Approx. Protein Concentrations	IgG concentration 0.5mg/ml
Immunogen	Synthetic peptide corresponding to aa 177-195 of mouse Mdm2.
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
ELISA	√	1/3000	1/12000
Western Blotting	√	1/500	1/2000
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls. Western Blotting AHP1329 detects a band of approximately 90kDa in mouse MEF cell lysates.
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文献
1. Wienken, M.et al.(2017) Mdm2 as a chromatin modifier.J Mol Cell Biol. 9 (1): 74-80.2. Oliner, J.D.et al.(2016) The Role of MDM2 Amplification and Overexpression in Tumorigenesis.Cold Spring Harb Perspect Med.6(6):a026336.3. Hou, H.et al.(2019) The role ofMDM2amplification and overexpression in therapeutic resistance of malignant tumors.Cancer Cell Int. 19: 216.

技术参数

产品应用 ELISA;WB

产品类型 Polyclonal Antibody

推荐用于 ELISA;WB

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Bio-Rad AHP1329 Mdm2,Rabbit anti Mouse Mdm2 antibody

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