Bio-Rad AHP1172 Bik,Rabbit anti Human Bik antibody-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Bio-Rad AHP1172 Bik,Rabbit anti Human Bik antibody

2024-10-22

Rabbit anti Human Bik antibody

货号：AHP1172

规格：0.1 mg

价格：2972

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：Bik

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：Purified

产品介绍
Rabbit anti Human Bik antibodyrecognizes the N-terminal (NT) region of Bcl-2-interacting killer (Bik) also known as natural born killer (Nbk). Bik is a Bcl-2 homology domain 3 (BH3)-only protein of ~18 kDa which requires the BAX gene for activation. Bik forms heterodimers with various antiapoptotic proteins such as Bcl-2 and Bcl-XL, inhibiting their antiapoptotic function. This can result in the release of Ca2+ and cytochrome C into the cytosol, leading to apoptosis.Loss of Bik is a common feature of clear-cell renal cell carcinoma (RCC), and is thought to act as a renal tissue-specific tumour suppressor gene.
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
Antiserum Preparation	Antisera to Bik were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Buffer Solution	Phosphate buffered saline
Preservative Stabilisers	0.02%Sodium Azide
Approx. Protein Concentrations	IgG concentration 1.0mg/ml
Immunogen	15 amino acid peptide from near the amino terminus of human Bik.
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
Immunohistology - Frozen	√
Western Blotting	√	1	2ug/ml
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage. Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. Western Blotting AHP1172 detects a band of approximately 18kDa in Jurkat cell lysates.
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Goat anti Rabbit IgG (Fc):Biotin	STAR121B	E;WB	1 mg
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数据
Immunocytochemical staining of Jurkat cells with Rabbit anti Human BIK (AHP1172).
文献
1. Mathai, J.P.et al.(2005) BH3-only BIK regulates BAX,BAK-dependent release of Ca2+ from endoplasmic reticulum stores and mitochondrial apoptosis during stress-induced cell death.J Biol Chem. 280 (25): 23829-36.2. Real, P.J.et al.(2006) Transcriptional activation of the proapoptotic bik gene by E2F proteins in cancer cells.FEBS Lett. 580 (25): 5905-9.3. Sturm, I.et al.(2006) Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma.Cell Death Differ. 13 (4): 619-27.

技术参数

产品应用 IHC(F);WB

产品类型 Polyclonal Antibody

推荐用于 IHC(F);WB

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Bio-Rad AHP1172 Bik,Rabbit anti Human Bik antibody

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