Bio-Rad AHP1171 BAG1,Rabbit anti Human BAG1 antibody-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Bio-Rad AHP1171 BAG1,Rabbit anti Human BAG1 antibody

2024-10-22

Rabbit anti Human BAG1 antibody

货号：AHP1171

规格：0.1 mg

价格：3672

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：BAG1

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：Purified

产品介绍
Rabbit anti Human BAG1 antibodyrecognizes the N-terminal (NT) region of Bcl-2 associated athanogene-1 (BAG1), a co-chaperone protein which binds to and regulates the 70 kDa heat shock proteins (Hsp70/Hsc70). BAG1 has also been shown to interact with the kinase Raf1, a number of steroid and tyrosine kinase receptors, and the Bcl-2 family of proteins. It is thought to function as a molecular switch between cell growth and differentiation, and cell survival.The BAG1 gene encodes three different isoforms; a predominantly cytosolic form of ~36 kDa (BAG1S), a ~46 kDa cytosolic and nuclear form (BAG1M), and a predominantly nuclear form of ~50 kDa (BAG1L).BAG1 displays potent neuroprotective activity in vivo against stroke, and could be used for reducing brain injury during cerebral ischemia and neurodegenerative diseases. BAG1 may also promote chemoresistance, growth factor independence, and anchorage independent cell growth in tumour cells.
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
Antiserum Preparation	Antisera to BAG1 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Buffer Solution	Phosphate buffered saline
Preservative Stabilisers	0.02%Sodium Azide
Approx. Protein Concentrations	IgG concentration 1.0mg/ml
Immunogen	14 amino acid peptide near the amino terminus of human BAG1.
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
Western Blotting	√	1	2ug/ml
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage. Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. Western Blotting AHP1171 detects a band of approximately 35kDa in PC-3 cell lysate.
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Description	Product Code	Applications	Pack Size
Goat anti Rabbit IgG (Fc):Biotin	STAR121B	E;WB	1 mg
Goat anti Rabbit IgG (Fc):FITC	STAR121F	Flow	1 mg
Goat anti Rabbit IgG (Fc):HRP	STAR121P	E;WB	1 mg
Goat anti Rabbit IgG (H/L):HRP	STAR124P	C;E;WB	1 mg
Sheep anti Rabbit IgG:FITC	STAR34B	C;F	1 mg
数据
Immunohistochemical staining of human lymph node with Rabbit anti Human BAG1 (AHP1171).
文献
1. Götz, R.et al.(2005) Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells.Nat Neurosci. 8 (9): 1169-78.2. Liman, J.et al.(2005) Interaction of BAG1 and Hsp70 mediates neuroprotectivity and increases chaperone activity.Mol Cell Biol. 25 (9): 3715-25.3. Krajewska, M.et al.(2006) Expression of BAG-1 protein correlates with aggressive behavior of prostate cancers.Prostate. 66 (8): 801-10.4. Clemo, N.K.et al.(2005) The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumour cell survival.Biochem Soc Trans. 33 (Pt 4): 676-8.

技术参数

产品应用 WB

产品类型 Polyclonal Antibody

推荐用于 WB

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Bio-Rad AHP1171 BAG1,Rabbit anti Human BAG1 antibody

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