Bio-Rad CD279抗体 AHP1705,Rabbit anti Human CD279 (C-Terminal)-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Bio-Rad CD279抗体 AHP1705,Rabbit anti Human CD279 (C-Terminal)

2024-10-22

Rabbit anti Human CD279 (C-Terminal)

货号：AHP1705

规格：0.1 mg

价格：5160

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原： CD279

物种：人

宿主：兔

抗体亚型：IgG3

荧光染料：Alexa Fluor 488

产品介绍
Rabbit anti Human CD279 antibodydetects CD279, a co-stimulatory molecule also known as programmed cell death-1 (PD-1). CD279 is a single-pass type 1 membrane protein belonging to the CD28 family, and functions mainly as a negative regulator of T-cell activation. CD279 has two specific ligands; CD274 (PD-L1) and CD273 (PD-L2), and their interaction is key in the balance between stimulatory and inhibitory signals needed for effective immune responses to microbes and self-tolerance. CD279 is inducibly expressed by T-cells, B-cells, NK-T-cells and monocytes upon activation.Loss of CD279 function has been associated with a number of autoimmune diseases, including rheumatoid arthritis, type I diabetes and ankylosing spondylitis. CD279 could be targeted therapeutically in the treatment of HIV infection to reduce T-cell exhaustion (Freemanet al.2006).
产品详情
Target Species	Human
Species Cross-Reactivity	Target SpeciesCross Reactivity
	Mouse√
	N.B. Antibody reactivity and working conditions may vary between species.
Product Form	Purified IgG - liquid
AntiserumPreparation	Antisera to Human CD279 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.
Buffer Solution	Phosphate buffered saline
Preservative Stabilisers	0.02% Sodium Azide (NaN₃)
Immunogen	A peptide corresponding to a 16 amino acid sequence from near the carboxy terminus of Human CD279.
Approx. Protein Concentrations	IgG concentration 1.0mg/ml
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
Immunohistology- Paraffin¹	√		2.5ug/ml
Western Blotting	√	0.5	1.0ug/ml
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.¹This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls. Histology Positive Control Tissue Human brain tissue Western Blotting AHP1705 detects a band of approximately 45kDa in THP-1 cell lysate
相关产品
Description	Product Code	Applications	Pack Size
Antigen Retrieval Buffer, pH8.0	BUF025A	P	500 ml
TidyBlot Western Blot Detection Reagent:HRP	STAR209P	WB*	0.5 ml
文献
1.Menke, J.et al.(2007) Programmed death 1 ligand (PD-L) 1 and PD-L2 limit autoimmune kidney disease: distinct roles.J Immunol. 179: 7466-77.2.Ishida, Y.et al.(1992) Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.EMBO J. 11 (11): 3887-95.3.Zhong, X. et al. (2004) Suppression of expression and function of negative immune regulator PD-1 by certain pattern recognition and cytokine receptor signals associated with immune system danger.Int. Immunol. 16:1181-84.Nishimura, H.et al.(1999) Development of lupus-like autoimmune diseases by the disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor.Immunity 11:141-51.

技术参数

产品应用 P*;WB

产品类型 Polyclonal Antibody

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Bio-Rad CD279抗体 AHP1705,Rabbit anti Human CD279 (C-Terminal)

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