Mouse anti Human elastase antibody, clone 39A bio-rad,Mouse anti Human elastase antibody, clone 39A-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Mouse anti Human elastase antibody, clone 39A bio-rad,Mouse anti Human elastase antibody, clone 39A

2024-10-22

Mouse anti Human elastase antibody, clone 39A

货号：4050-0096

规格：0.2 mg

价格：3043

产品类型：免疫组化一抗

品牌：Bio-Rad

物种：人

宿主：小鼠

抗体亚型：IgG1

克隆号：ELA10-101.5 (39A)

荧光染料：Purified

产品介绍
Mouse anti Human elastase antibody, clone 39Arecognizes human neutrophil elastase, also known as elastase-2, Bone marrow serine protease, PMN elastase or Medullasin. Elastase is a 238 amino acid ~27 kDa enzyme with an addiional 29 amino acid signal and pro-peptide region. Mutations of the ELA2 gene can lead to a number of hematopoietic disorders including cyclic hematopoiesis (CH) characterized by a 21 day cycle of bone marrow derived blood cell production with neutrophil numbers ranging between normal levels and almost zero (Horwitzet al.1999) and severe congential autosomal neutropenia (SCN1) demonstating developmental arrest of granulopoiesis at the promyelocyte stage (Bellanné-Chantelotet al.2004) with both conditions leading to a predisposition to bacterial infections..
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
Preparation	Purified IgG prepared by affinity chromatography on Protein G
Buffer Solution	Phosphate buffered saline
Preservative Stabilisers	<0.1% Sodium Azide (NaN3)5% Trehalose
Immunogen	Elastase from human neutrophils.
Approx. Protein Concentrations	1.0 mg/ml
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
ELISA	√
Flow Cytometry	√
Functional Assays	√
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
二抗
Description	Product Code	Applications	Pack Size
Goat anti Mouse IgG (H/L):FITC (Multi Species Adsorbed)	STAR117F	F	0.5mg
Goat anti Mouse IgG (H/L):Alk. Phos. (Multi Species Adsorbed)	STAR117A	E,WB	0.5mg
文献
1.Durant, S.et al.(2004) Apoptosis-induced proteinase 3 membrane expression is independent from degranulation.J Leukoc Biol. 75 (1): 87-98.2.Vong, L.et al.(2007) Annexin 1 cleavage in activated neutrophils: a pivotal role for proteinase 3.J Biol Chem. 282 (41): 29998-30004.3.Davies, P.L.et al.(2008) Monoclonal anti-neutrophil elastase antibody characterisation: ability to block function, detect free versus serpin-complexed enzyme and stain intracellular granules.J Immunol Methods. 336 (2): 175-82.4.Muthana, M.et al.(2015) C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis.Proc Natl Acad Sci U S A. 112 (37): 11618-23.5.Buján, J.et al.(2003) Expression of elastic components in healthy and varicose veins.World J Surg. 27 (8): 901-5.6.Korkmaz, B.et al.(2005) Inhibition of neutrophil elastase by alpha1-protease inhibitor at the surface of human polymorphonuclear neutrophils.J Immunol. 175 (5): 3329-38.

技术参数

产品应用 Elisa;Flow

产品类型 Monoclonal Antibody

推荐用于 Elisa;Flow

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Mouse anti Human elastase antibody, clone 39A bio-rad,Mouse anti Human elastase antibody, clone 39A

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