Recombinant Human VEGF-C
货号：100-20CD-100,100-20CD-1000,100-20CD-20,100-20CD-250,100-20CD-5,100-20CD-500
规格：100ug,1mg,20ug,250ug,5ug,500ug
价格：7016,28131,1560,12277,640,18247
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：VEGF-C, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-C is expressed in various tissues, but is not produced in peripheral blood lymphocytes. It forms cell surfaced-associated, non-covalent, disulfide-linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-C may play a role in the formation of the venous and lymphatic vascular systems. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant Human VEGF-C is a disulfide-linked homodimeric protein consisting of two 13.5 kDa polypeptide chains of 116 amino acid residues. Due to glycosylation, the protein migrates as a 30.0-33.0 kDa band by SDS-PAGE analysis under non-reducing conditions.来源:HEK293 cells别名:Vascular Endothelial Growth Factor-C, VRP, Flt4 ligand氨基酸序列 (monomer):AHYNTEILKS IDNEWRKTQC MPREVCIDVG KEFGVATNTF FKPPCVSVYR CGGCCNSEGL QCMNTSTSYL SKTLFEITVP LSQGPKPVTI SFANHTSCRC MSKLDVYRQV HSIIRR纯度:≥ 95% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by its ability to stimulate the proliferation of human microvascular endothelial cells (HMVEC) in low serum conditions.Calculated Molecular Weight:26.2 kDaAccession Number:P49767Gene ID:7424交叉反应:Human,Mouse原产地:USA仅用于科研，不能用于临床。 |
product.subtitle.recentcitations |
第一作者 | Zhang, Y |
标题 | Lymphangiogenesis in renal fibrosis arises from macrophages via VEGF-C/VEGFR3-dependent autophagy and polarization. |
文献引用 | Cell death & disease; 12(1) pg109 |
PubMed Id | 33479195 |
第一作者 | Zhang, L |
标题 | Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer. |
文献引用 | Cell; 181(2) pg442-459.e29 |
PubMed Id | 32302573 |
第一作者 | Lin, T |
标题 | TGFBIp mediates lymphatic sprouting in corneal lymphangiogenesis. |
文献引用 | Journal of Cellular and Molecular Medicine; 23(11) pg7602-7616 |
PubMed Id | 31456353 |
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