Animal-Free Recombinant Human sTNF Receptor Type I

货号：AF-310-07-100,AF-310-07-1000,AF-310-07-20,AF-310-07-250,AF-310-07-5,AF-310-07-500

规格：100ug,1mg,20ug,250ug,5ug,500ug

价格：12700,50820,2830,22230,1250,33030

产品类型：细胞生物学

品牌：PeproTech

产品描述：TNFRI belongs to the TNFR superfamily of transmembrane proteins, and is expressed in most cell types. Binding of either TNF-α or TNF-β to TNFRI initiates a signal transduction pathway that results in the activation of the transduction factor NF-κB, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells induce apoptosis. Soluble TNF Receptor I (sTNFRI) is capable of inhibiting TNF-α and TNF-β activities by acting as a decoy receptor that serves as a sink for the TNF ligands. The human TNFRI gene encodes for a 455 amino acid type I transmembrane protein, which contains a 21 amino acid signal sequence, a 190 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 221 amino acid cytoplasmic domain. Recombinant Human sTNF Receptor Type I is an 18.3 kDa protein (162 amino acid residues) comprising the cysteine-rich, ligand-binding portion of the extracellular domain of the TNFRI protein.Manufactured using all Animal-Free reagents.来源:E.coli别名:soluble Tumor Necrosis Factor Type I, TNFRSF1A, TNFAR, p60, p55, CD120a, TNFR1氨基酸序列:MDSVCPQGKY IHPQNNSICC TKCHKGTYLY NDCPGPGQDT DCRECESGSF TASENHLRHC LSCSKCRKEM GQVEISSCTV DRDTVCGCRK NQYRHYWSEN LFQCFNCSLC LNGTVHLSCQ EKQNTVCTCH AGFFLRENEC VSCSNCKKSL ECTKLCLPQI EN纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by its inhibitory effect of the TNF-α mediated cytotoxicity in murine L-929 cells. The ED₅₀ for this effect in the presence of 0.25 ng/ml of Recombinant Human TNF-α, is 0.05 µg/ml.Calculated Molecular Weight:18.3 kDaAccession Number:P19438Gene ID:7132

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